Impaired Stepping as a Risk Factor for Falls in Older People

Background

Protective stepping is crucial for balance control and recovery. A step made to restore balance must have the right timing, direction and size for it to succeed. Initial studies have shown that inappropriate step responses are significantly more prevalent in older compared to younger people. Impaired stepping is even more common in older people at risk of falls and those with balance impairments, suggesting that appropriate stepping responses are crucial for falls prevention. However, no studies have comprehensively examined stepping performance as a risk factor for falls in a prospective study.

Aims

We propose to systematically investigate sensory, motor, neural, mechanical and psychological determinants of appropriate and impaired responses to postural perturbations and determine the role that impaired stepping plays in falls. Much of this work will be addressed in a large prospective cohort study, with two targeted experimental studies undertaken to identify the effects of fatigue and divided attention on stepping performance and balance control. The final study will comprise an RCT to evaluate the effects of a training intervention to improve balance and stepping performance in older adults. This body of work will provide the framework from which to conduct a subsequent RCT with falls or fall injuries as the primary outcome measure.

Procedures

Stepping will be assessed using a novel multi-directional wait-pull perturbation protocol that initiates a step response in an unexpected direction and time. This research comprises four distinct studies.

  1. A large prospective cohort study of 300 older community-dwelling adults, to examine longitudinal changes in stepping responses and assess the effects of impaired stepping performance on the incidence of falls. This study will also measure the prevalence of impaired stepping in older people and examine associations and interactions between stepping performance and a range of physiological, pathological, psychological and sociological factors. We will develop an explanatory model of the association between impaired stepping and falls.
  2. An experimental investigation of the influence of muscle fatigue on stepping performance. Participants in this study will undergo lower limb muscle fatiguing protocols to determine the impact of fatigue on the force threshold, accuracy and success of the stepping response.
  3. An experimental investigation of the influence of cognitive distraction on stepping performance. Stepping will be evoked while subjects perform a visuospatial working memory task. This cognitive distracter is expected to adversely affect stepping and this study will identify what aspects of the step are affected by limited cognitive resources.
  4. A randomised controlled trial of the effects of a training intervention to improve balance and stepping performance and reduce fall risk in older adults. The intervention will be informed by the results of studies A-C and address the hypothesis that the changes in stepping performance can be improved via a specific exercise program, emphasising stepping timing and accuracy.

Expected Outcomes and Significance

It is hypothesised that impaired stepping will be an important risk factor for falls in older adults. A systematic and comprehensive approach to quantification of risk will reveal complex non-linear associations and interactions between the stepping measures and a range of measured physiological, pathological, psychological and sociological factors. Our proposed project will develop an explanatory model of impaired stepping and falls. We will develop a low tech test suitable for use in clinical practice to enhance falls risk assessment, and lay a solid foundation from which exercise programs can be enhanced to provide safe, appropriate and effective interventions.

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