One of the characteristic features of the vulnerable neurons in Parkinson’s disease is that they contain dopamine, a neurotransmitter known to convey a high oxidative load upon cells due to its capacity for autoxidation, as well as enzymatic metabolism. To date the oxidative pathways of dopamine, particularly in the presence of iron, have not been characterised. This project aims to understand the oxidative neurochemistry of this vital neurotransmitter and its influence on the healthy and diseased human brain. This project is a collaboration with Professor David Waite, Civil and Environmental Engineering, UNSW.
This project is suitable for an ILP, Honours or PhD project for a student with a strong chemistry background. Contact Assoc Prof Double for more information.
Key researchers:
Dr Ninh Pham, Civil and Environmental Engineering, UNSW
