New neuron birth, or neurogenesis, continues in the subventricular zone and dentate gyrus of adult brain. This process has been linked with memory, anxiety, addiction and olfaction. Studies in non-human species suggest that there is a marked decline in the number of newly generated neurons with aging. For example, the number of proliferating cells in the hippocampus decreases by approximately 50% during the adult marmoset lifespan. This decline may have functional consequences as age-related decreases in adult neurogenesis have been linked to a decline in olfactory and memory ability in aging animals. These memory deficits can be partially prevented when the age-related decline in neurogenesis is reduced.
Little is known about age-related changes in the level of adult human neurogenesis and the factors that regulate it. This project is examining whether neurogenesis, and levels of factors regulating neurogenesis, are altered with age across the human lifespan. Information derived from this study will be critical for an understanding of how neurogenesis is regulated within the adult human brain. Such knowledge is important for current research which aims to develop novel therapeutic approaches for neurodegenerative disease based upon stimulating endogenous neurogenesis or transplanting new neurons into the human brain.
This project is suitable for an ILP, Honours or PhD project. Contact Assoc Prof Double for more information.
Key researchers:
