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Halliday Group - Professor Glenda Halliday

The Halliday group concentrates on understanding the tissue changes associated with neurodegenerative dementias and movement disorders in order to develop mechanistic treatments and diagnostic tools. They assess a number of factors including 1) predisposing factors like genetic makeup (using gene screening techniques), 2) the degree of neuronal degeneration and tissue loss over time (using quantitative imaging in vivo and physical stereology postmortem), 3) physical changes in remaining brain cells and tissues (using cell staining techniques mainly at light but also electron microscope levels), 4) molecular changes in brain tissue over time (mainly protein changes using Western blotting, but also other techniques), 5) the onset of different clinical features (using longitudinal clinical evaluations), 6) blood protein markers of the different pathologies (using ELISA techniques), and use animal and cellular models to determine biological relationships and test modifying treatments. This research is aimed at identifying early versus later events in neurodegenerative disorders, both aspects suitable for targeting to either arrest disease onset or stop progression once the disease has begun, and also to more reliably detect the underlying protein changes in patients. In addition to the laboratory work, these studies involve the co-ordination of clinical studies that longitudinally follow patients with diagnoses of neurodegenerative movement disorders and dementias, and non-affected controls, studies where the participants have agreed to donate serial blood samples and their brain and spinal cord tissue at death.

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Senior Principal Research Fellow, NHMRC (2010 - 2019)
Professor of Neuroscience, School of Medical Sciences, UNSW Medicine (2008 - 2018)
Conjoint Senior Principal Research Fellow, NeuRA (2003 - 2018)
Director, Sydney Brain Bank, UNSW and NeuRA (2008 - 2018)
T: +612 9399 1704
E: no-email@neura.edu.au

Prof Glenda Halliday is an Australian Professor of Neuroscience leading a research program of ~70 researchers tackling non-Alzheimer's neurodegeneration that stems from her work on frontotemporal and motor neurodegenerative syndromes, and Parkinson’s disease. She is also Director of the Sydney Brain Bank. She received her degrees at University of New South Wales, and postdoctoral training at Flinders University prior to an ARC Queen Elizabeth II Fellow and NHMRC research fellowships since 1988, joining NeuRA in 1993. She has published >300 research papers and 2 books, and attracted >$30m in grant funding. Prof Halliday is on the editorial boards of 5 international journals, on Scientific Advisory Boards for 3 research institutes (one international), and is a committee member for a number of international organizations, including the International Brain Research Organization (a member organization of UNESCO). She was elected president of the Australian Neuroscience Society (ANS 2006-2007), awarded the 2011 ANS Nina Kondelos Prize, and named a high achiever in Australian Health and Medical Research by NHMRC.

Alzheimer's disease

Is Alzheimer's disease the same in centenarians?

Frontotemporal dementia and related disorders

Long non-coding RNAs in frontotemporal dementia

Parkinson's disease and related syndromes

Investigating whether SNCA genetic variation relates to pathological variation in Parkinson’s disease

Research team 
Prof Glenda Halliday's picture
Professor Glenda Halliday
Senior Principal Research Fellow, NHMRC (2010 - 2019)
Professor of Neuroscience, School of Medical Sciences, UNSW Medicine (2008 - 2018)
T: +612 9399 1704
E: no-email@neura.edu.au
Dr Scott Kim's picture
Dr Scott Kim
Senior Research Officer
Conjoint Senior Lecturer, School of Medical Sciences, UNSW
T: +612 9399 1084
E: w.kim@neura.edu.au
Dr Rachel Tan's picture
Dr Rachel Tan
Research Officer
T: +612 9399 1151
E: r.tan@neura.du.au
Ms Heidi Cartwright's picture
Heidi Cartwright
P/T Senior Research Assistant
T: +612 9399 1823
E: h.cartwright@neura.edu.au
Gayathri Perera's picture
Ani Lack's picture
Ani Lack
Research Assistant
Surabhi Bhatia's picture
Surabhi Bhatia
P/T Research Officer
T: +612 9399 1802
E: s.bhatia@neura.edu.au
Kelly Cao's picture
Kelly Cao
Honours Student