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Karl Group - Associate Professor Tim Karl

The Karl Group is interested in understanding mental and neurodegenerative disorders such as schizophrenia and Alzheimer’s disease. Assoc Prof Karl’s team applies behavioural phenotyping techniques and uses pharmacological tools to determine gene-environment interactions (GxE) in the development of these illnesses. Another focus is on the role of the endocannabinoid system in these disorders and the detrimental and sometimes therapeutic effects of cannabis plant constituents.

Assoc Prof Karl’s research also explores ways to increase the relevance and validity of animal models for preclinical medical research. Thus, the Karl team evaluates the effects of housing conditions (e.g. different cage systems) on the neurobehavioral phenotype of animal models. Furthermore, the team develops new, advanced test paradigms to characterise mouse mutants for medical research more comprehensively.

Click here to access Assoc Prof Tim Karl's research papers:

ORCID ID: 0000-0001-9904-8482
NHMRC R.D. Wright Biomedical Research Fellow (Level 2)
Principal Research Fellow, NeuRA
Conjoint Associate Professor, UNSW
Member of the Animal Care and Ethics Committee, UNSW
T: +612 9399 1838
E: t.karl@neura.edu.au

Tim Karl graduated from the Leipniz University of Hannover (Germany) in 2003 with a PhD in Zoology (Behavioural Neuroscience). Until 2008, he was a postdoctoral researcher at the Garvan Institute of Medical Research working on rodent models for anxiety and schizophrenia. In 2008, Tim Karl established his own research team at NeuRA. His research focuses on the neuro-behavioural consequences of gene-environment interactions in animal models for brain disorders (e.g. schizophrenia and Alzheimer's disease). He also aims to enhance the validity of rodent models and the well-being of test animals in medical research by providing more stimulating housing conditions.Tim's research has attracted funding from the National Health and Medical Research Council, the Motor Neuron Disease Research Institute of Australia, the Brain and Behavior Research Foundation (USA), the German Research Foundation and other funding bodies (e.g. Mason Foundation National Research Program).

Environmental enrichment in animal model research

Behavioural, cellular and molecular studies have revealed a significant beneficial impact of environmental enrichment (EE; housing conditions that facilitate enhanced sensory, cognitive and motor stim

Genetic mouse models for schizophrenia: the candidate gene neuregulin 1

Schizophrenia (SCZ) is a chronic and disabling mental disorder that affects 1% of the world’s population. Neither environment nor genetics alone are sufficient to cause SCZ.

The role of the endocannabinoid system in Alzheimer’s disease

Alzheimer’s disease (AD) is neurodegenerative cognitive disorder with an inflammatory component.

Research team 
Dr Tim Karl's picture
Associate Professor Tim Karl
NHMRC R.D. Wright Biomedical Research Fellow (Level 2)
Principal Research Fellow, NeuRA
T: +612 9399 1838
E: t.karl@neura.edu.au
Jerzy Zieba's picture
Jerzy Zieba
Research Assistant
Kani Shang's picture
Kani Shang
Research Assistant
Georgia Watt's picture