2012-2016. National Health and Medical Research Council Research Fellowship (NHMRC).
SRF A (Weickert CS) $580,910
2012-2016. National Health and Medical Research Council Research Fellowship (NHMRC).
SRF A (Weickert CS) $580,910
National Health and Medical Research Council Project Grant (NHMRC) - $328,175
Bipolar disorder (BD) and schizophrenia (Sz) share dysfunction in prefrontal inhibitory brain systems, yet exhibit distinct forms of affective disturbance.
Excitement and controversy have followed neuregulin (NRG1) since its discovery as a putative schizophrenia susceptibility gene; however, the mechanism of action of the associated risk haplotype (HapIC
An increase in apoptotic events may underlie neuropathology in schizophrenia.
Abnormal patterns of HPA axis activation, under basal conditions and in response to stress, are found in individuals with schizophrenia and bipolar disorder.
Reward detection, surprise detection and prediction-error signaling have all been proposed as roles for the ventral striatum (vStr).
Abstract Objectives. Cancer incidence in schizophrenia is not increased commensurate with higher rates of risk exposures.
Wong, J., Duncan, C., Beveridge, N., Webster, M., Cairns, M. and Shannon Weickert, C. Expression of NPAS3in the human cortex and evidence of its post-transcriptional regulation by miR-17 during development, with implications for schizophrenia. Schizophrenia Bulletin, doi: 10.1093/schbul/sbr177, 6 January 2012 [Epub ahead of print].
NPAS3 is a developmentally important transcription factor that has been associated with psychiatric illness.
Serotonin and its receptors (HTRs) play critical roles in brain development and in the regulation of cognition, mood, and anxiety.
Neuroimaging studies have shown both dorsolateral prefrontal (DLPFC) and inferior parietal cortex (iPARC) activation during probabilistic association learning.
Background: Interstitial white matter neurons (IWMNs) may reflect immature neurons that migrate tangentially to the neocortex from the ganglionic eminence to form cortical interneurons.
Background: Reduced synaptic connectivity in frontal cortex may contribute to schizophrenia symptoms.
Postnatal neurogenesis occurs in the subventricular zone and dentate gyrus, and evidence suggests that new neurons may be present in additional regions of the mature primate brain, including the prefr
In this study, we determined if estrogen receptor alpha (ERα) can interact with the full length tropomyosin receptor kinase B (TrkB-TK+), both of which are implicated in schizophrenia pathogenesis.
A number of studies suggest a dysregulation of the endogenous cannabinoid system in schizophrenia (SCZ).
Background: Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor (trkB-TK+) and glutamic acid decarboxylase (GAD67) mRNA levels have previously been found to be reduced in the prefrontal
Stress has been implicated in the onset and illness course of schizophrenia and bipolar disorder.
Theories concerning the pathology of human neurodevelopmental disorders that emerge in adolescence, such as schizophrenia, often hypothesize that there may be a failure of normal cortical synaptic los
Brain-derived neurotrophic factor (BDNF) regulates the survival and growth of neurons, and influences synaptic efficiency and plasticity.
The glucocorticoid receptor (GR) has a critical role in determining the brain’s capacity to
respond to stress, and has been implicated in the pathogenesis of psychiatric illness. We
A balance between excitatory and inhibitory neurotransmission is important in normal brain function, and in schizophrenia a deficit in γ-aminobutyric acid (GABA)ergic inhibitory neurotransmission has
Schizophrenia is associated with heterogeneity in symptoms, cognition and treatment response.
