Biomarkers in healthy adults and healthy siblings of people with schizophrenia

RESEARCH STUDY

Would the research project be a good fit for me?

The study might be good for you if:

  • You are between the ages of 18-60 and you are a healthy adult with or without a sibling who has a diagnosis of schizophrenia or schizoaffective disorder
  • You DO NOT have a personal history of schizophrenia, seizures, substance abuse or dependence (within past 3 years), head injury or loss of consciousness, central nervous system infections

What would happen if I took part in the research project?

If you decide to take part you would visit Neuroscience Research Australia to complete the following:

  • Perform cognitive tests and questionnaires (within 2 hours)
  • Provide a blood sample
  • Receive a short medical examination including a visual eye, nose, and throat exam, lungs and heart (using stethoscope) exam, body temperature, blood pressure, and brief medical history
  • Receive an MRI scan (approx. 1 hr) which includes performing computer-based cognitive tests

Will I be paid to take part in the research project?

You will be reimbursed $60 for this visit and any reasonable travel, parking, or other expenses associated with the research project visit.

Who do I contact if I want more information or want to take part in the study?

If you would like more information or are interested in being part of the study please contact:

See what’s going on at NeuRA

FEEL THE BUZZ IN THE AIR? US TOO.

Brain and Knee Muscle Weakness Study

Why Does Quadriceps Weakness Persist after Total Knee Replacement? An Exploration of Neurophysiological Mechanisms Total knee replacement is a commonly performed surgery for treating end-staged knee osteoarthritis. Although most people recover well after surgery, weakness of the quadriceps muscles (the front thigh muscles) persists long after the surgery (at least for 12 months), despite intensive physiotherapy and exercise. Quadriceps muscle weakness is known to be associated with more severe pain and greatly affect daily activities. This study aims to investigate the mechanisms underlying weakness of the quadriceps muscles in people with knee osteoarthritis and total knee replacement. We hope to better understand the relationship between the changes of the brain and a loss of quadriceps muscle strength after total knee replacement. The study might be a good fit for you if you: Scheduled to undergo a total knee replacement; The surgery is scheduled within the next 4 weeks; Do not have a previous knee joint replacement in the same knee; Do not have high tibial osteotomy; Do not have neurological disorders, epilepsy, psychiatric conditions, other chronic pain conditions; Do not have metal implants in the skull; Do not have a loss of sensation in the limbs. If you decide to take part you would: Be contacted by the researcher to determine your eligibility for the study Be scheduled for testing if you are eligible and willing to take part in the study Sign the Consent Form when you attend the first testing session Attend 3 testing sessions (approximately 2 hours per session): 1) before total knee replacement, 2) 3 months and 3) 6 months after total knee replacement. The testing will include several non-invasive measures of brain representations of the quadriceps muscles, central pain mechanisms, and motor function and questionnaires. Will I be paid to take part in the research study? You will be reimbursed ($50.00 per session) for travel and parking expenses associated with the research study visits. If you would like more information or are interested in being part of the study, please contact: Name: Dr Wei-Ju Chang Email: w.chang@neura.edu.au Phone: 02 9399 1260 This research is being funded by the Physiotherapy Research Foundation.  
PROJECT