Brain control of movement

RESEARCH STUDY

How the brain controls movement

We are looking for volunteers to participate in a study of how the brain controls movement and how the brain compensates when there is damage to brain regions that control movement.

To participate, you must be aged 50-70 years with no neurological condition or mental illness and live in either the Sydney or Adelaide metropolitan region.

We are also looking for individuals with:

  • restless legs syndrome
  • Parkinson’s disease

The study will involve an ultrasound of your head to obtain a picture of your brain. A neurologist will examine your movements and you will be asked to complete a short series of tests to assess thinking and memory. Some volunteers will then be asked to undergo magnetic resonance imaging (MRI) and magnetic stimulation of the brain. Both procedures are safe, painless, and are routinely used in clinical and research settings.

 

See what’s going on at NeuRA

FEEL THE BUZZ IN THE AIR? US TOO.

Caress the Detail: A Comprehensive MRI Atlas of the in Vivo Human Brain

This project aims to deliver the most comprehensive, detailed and stereotaxically accurate MRI atlas of the canonical human brain. In human neuroscience, researchers and clinicians almost always investigate images obtained from living individuals. Yet, there is no satisfactory MRI atlas of the human brain in vivo or post-mortem. There are some population-based atlases, which valiantly solve a number of problems, but they fail to address major needs. Most problematically, they segment only a small number of brain structures, typically about 50, and they are of limited value for the interpretation of a single subject/patient. In contrast to population-based approaches, the present project will investigate normal, living subjects in detail. We aim to define approximately 800 structures, as in the histological atlas of Mai, Majtanik and Paxinos (2016), and, thus, provide a “gold standard” for science and clinical practice. We will do this by obtaining high-resolution MRI at 3T and 7T of twelve subjects through a collaboration with Markus Barth from the Centre for Advanced Imaging at the University of Queensland (UQ). The limited number of subjects will allow us to image each for longer periods, obtaining higher resolution and contrast, and to invest the required time to produce unprecedented detail in segmentation. We will produce an electronic atlas for interpreting MR images, both as a tablet application and as an online web service. The tablet application will provide a convenient and powerful exegesis of brain anatomy for researchers and clinicians. The open access web service will additionally provide images, segmentation and anatomical templates to be used with most common MR-analysis packages (e.g., SPM, FSL, MINC, BrainVoyager). This will be hosted in collaboration with UQ, supporting and complementing their population-based atlas.
PROJECT