David Foxe with FTD study participant

FTD & Alzheimer's disease

RESEARCH STUDY

FRONTOTEMPORAL DEMENTIA AND ALZHEIMER’S DISEASE STUDY

The Frontier team is currently recruiting healthy adults, aged 50 years and over, for research aiding the diagnosis and treatment of dementia syndromes including frontotemporal dementia and Alzheimer’s disease. Our group examines the cognitive, behavioural, psychological, and brain changes in individuals with dementia and measures their impact on patients and their families. Our group is also studying how changes in dementia differ from those seen in other brain disorders and in healthy ageing, to help improve the diagnosis of dementia.

As part of this research, we require healthy volunteers to act as a comparison group. Participation in this study can involve a number of different tests of memory, language and other thinking abilities. We may also ask to take a blood sample, and an MRI brain scan may be offered. This all takes place at the NeuRA institute (any travelling costs will be reimbursed).

If you are interested, or for more information, please contact frontier@neura.edu.au

See what’s going on at NeuRA

FEEL THE BUZZ IN THE AIR? US TOO.

Caress the Detail: A Comprehensive MRI Atlas of the in Vivo Human Brain

This project aims to deliver the most comprehensive, detailed and stereotaxically accurate MRI atlas of the canonical human brain. In human neuroscience, researchers and clinicians almost always investigate images obtained from living individuals. Yet, there is no satisfactory MRI atlas of the human brain in vivo or post-mortem. There are some population-based atlases, which valiantly solve a number of problems, but they fail to address major needs. Most problematically, they segment only a small number of brain structures, typically about 50, and they are of limited value for the interpretation of a single subject/patient. In contrast to population-based approaches, the present project will investigate normal, living subjects in detail. We aim to define approximately 800 structures, as in the histological atlas of Mai, Majtanik and Paxinos (2016), and, thus, provide a “gold standard” for science and clinical practice. We will do this by obtaining high-resolution MRI at 3T and 7T of twelve subjects through a collaboration with Markus Barth from the Centre for Advanced Imaging at the University of Queensland (UQ). The limited number of subjects will allow us to image each for longer periods, obtaining higher resolution and contrast, and to invest the required time to produce unprecedented detail in segmentation. We will produce an electronic atlas for interpreting MR images, both as a tablet application and as an online web service. The tablet application will provide a convenient and powerful exegesis of brain anatomy for researchers and clinicians. The open access web service will additionally provide images, segmentation and anatomical templates to be used with most common MR-analysis packages (e.g., SPM, FSL, MINC, BrainVoyager). This will be hosted in collaboration with UQ, supporting and complementing their population-based atlas.
PROJECT