HIV-associated dementia

RESEARCH STUDY

We are currently recruiting healthy men aged 45 years and over for a study investigating the link between HIV infection and dementia.

In conjunction with St Vincent’s Hospital, the University of New South Wales and Neuroscience Research Australia (NeuRA), the study aims to estimate the prevalence of memory and concentration difficulties in older individuals with long-term HIV infection, as well as the means (if any) by which long-term HIV infection contributes to the incidence of an illness like dementia.

An important part of this study is recruiting healthy control participants as a comparison group. To participate, you must be:

  • male
  • 45 years old or older
  • in good health, with no psychiatric or neurological disoders

We will ask you to make two visits to St Vincent’s Hospital in Sydney over an 18 month period. Each visit will last two hours, during which we will ask you to participate in a neuropsychological test of attention, memory, visuo-spatial and language function. We will also ask to take an MRI scan of your head (this involves lying quietly in the MRI scanner for 45 minutes).

If you so chose, we can make the study results available to your doctor of choice. We will reimburse your travel/parking expenses.

To participate, or for more information contact Dr Lucette Cysique on 0431 576 710 or via email: lcysique@unsw.edu.au

 

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Brain and Knee Muscle Weakness Study

Why Does Quadriceps Weakness Persist after Total Knee Replacement? An Exploration of Neurophysiological Mechanisms Total knee replacement is a commonly performed surgery for treating end-staged knee osteoarthritis. Although most people recover well after surgery, weakness of the quadriceps muscles (the front thigh muscles) persists long after the surgery (at least for 12 months), despite intensive physiotherapy and exercise. Quadriceps muscle weakness is known to be associated with more severe pain and greatly affect daily activities. This study aims to investigate the mechanisms underlying weakness of the quadriceps muscles in people with knee osteoarthritis and total knee replacement. We hope to better understand the relationship between the changes of the brain and a loss of quadriceps muscle strength after total knee replacement. The study might be a good fit for you if you: Scheduled to undergo a total knee replacement; The surgery is scheduled within the next 4 weeks; Do not have a previous knee joint replacement in the same knee; Do not have high tibial osteotomy; Do not have neurological disorders, epilepsy, psychiatric conditions, other chronic pain conditions; Do not have metal implants in the skull; Do not have a loss of sensation in the limbs. If you decide to take part you would: Be contacted by the researcher to determine your eligibility for the study Be scheduled for testing if you are eligible and willing to take part in the study Sign the Consent Form when you attend the first testing session Attend 3 testing sessions (approximately 2 hours per session): 1) before total knee replacement, 2) 3 months and 3) 6 months after total knee replacement. The testing will include several non-invasive measures of brain representations of the quadriceps muscles, central pain mechanisms, and motor function and questionnaires. Will I be paid to take part in the research study? You will be reimbursed ($50.00 per session) for travel and parking expenses associated with the research study visits. If you would like more information or are interested in being part of the study, please contact: Name: Dr Wei-Ju Chang Email: w.chang@neura.edu.au Phone: 02 9399 1260 This research is being funded by the Physiotherapy Research Foundation.  
PROJECT