Within the central nervous system, we have identified three sites that can potentially cause respiratory issues; (1) the sensorimotor cortex, (2) the medullary respiratory centres, and (3) spinal reflex circuits. We are currently using a multi-faceted approach to investigate each of these three potential sites of failure of respiratory neural control, thus determining the central mechanisms of respiratory motor impairment.
Our team is uniquely qualified to apply a suite of specialised neurophysiological methods, many pioneered in our lab, to better understand voluntary activation of the diaphragm, cortical activation during breathing, and measure single motor unit activity.
A motor unit is made up of a motor neuron and the muscle it activates. We are the only group internationally who make motor unit recordings from human respiratory pump muscles. This is the only direct measure of neural drive.
Our current experiments are looking at voluntary and involuntary drive to the breathing muscles to try to answer this fundamental question about the neural control of breathing. In addition, we are looking at the potential cortical contributions to resting breathing in respiratory disorders.
Chronic Obstructive Pulmonary Disease
Respiratory impairment is a common and debilitating medical condition for older adults and people with chronic obstructive pulmonary disease (COPD). This condition is the third-highest ranking disease burden in Australia and New Zealand.
Respiratory illness limits daily activities and reduces health-related quality of life. These consequences and frequent hospitalisations are a public health burden that cost over $1 billion per year.
Spinal cord injury
After cervical spinal cord injury (SCI), the respiratory muscles are partly or completely paralysed. There are two major clinical consequences of this: the ability to get air into the lungs is diminished as is the ability to cough to remove secretions. This results in a lifetime of recurrent respiratory tract infections (2/year/person) that often proceed to pneumonia and frequent hospitalisations.
People with cervical SCI are 150 times more likely to die from respiratory complications than the general population. A recent longitudinal study of 283 people with cervical SCI showed that respiratory muscle weakness is linked to incidental pneumonia. There is an urgent need to identify a simple and effective treatment for weak respiratory muscles and the prevention of respiratory complications after SCI.
Obstructive Sleep Apnoea
OSA is a sleep disorder that affects more than 4 percent of the population and can lead to symptoms from daytime drowsiness to high blood pressure. People with sleep apnoea are often not breathing normally during sleep and may experience periods where the airway closes and they are unable to breathe. In severe sleep apnoea this can occur 50-60 times each hour. That is once each minute.
The closure of the upper airway is thought to be due to a number of factors, one of which is that the neural drive to the airway muscles is insufficient in people with sleep apnoea. In our lab, we have made the first extensive recordings from the major muscle of the upper airway, genioglossus.
We have shown that the neural drive to this muscle is very complex, more so than any limb muscle. At NeuRA, we have also pioneered new methods to image this muscle using fMRI and ultrasound. We are now planning to look at how changes in muscle architecture and mechanics relate to the neural drive to the muscle and whether that relationship is maintained in people with sleep apnoea.
On August 11 2019, 54 people took on the City2Surf for Neuroscience Research Australia (NeuRA). The event is the world’s largest fun run with 80,000 participants taking on the 14km course, which stretches from Hyde Park in central Sydney to the iconic Bondi Beach. NeuRA thanks all of its fundraisers, who raised an incredible $30,903. This funding will further NeuRA’s […]