Depression is more than just tearfulness or feelings of sadness. It refers to a range of mood and other symptoms that are intense, long-lasting and distressing to the person. These symptoms will likely interfere with a person’s day-to-day life and relationships.
The causes of depression can vary from person to person. For some, stressful life events such as the loss of a relationship or job, long-term unemployment, physical health issues, family problems, or the death of a loved one might trigger depression. For others, there is no obvious cause.
In a collaborative study with Professors Kay Wilhelm and Phil Mitchell from the UNSW School of Psychiatry, Professor Peter Schofield and his team examined the genetic variation in the transporter protein that is involved in the reuptake of the neurotransmitter serotonin. There is an association between low serotonin transporter levels, stress and depression. The group has further shown that there is an association between the serotonin transporter genotypes and the way an individual copes with stress. This has led to further clinical studies correlating how individuals can use different methods to handle stress. Their research has significant implications for reducing the likelihood of developing depression and a planned future study will be to evaluate whether specific training in stress management, matched to an individual’s genotype, may lead to a reduction in the incidence of depression.
Epigenetics is the study of how our environment influences the expression of our genes. My group has found a link between early life experiences and attention. Exposure to traumatic experiences in the early stages of life, including abuse or neglect, parental divorce or mental illness, and poverty, are known to influence the development of some mental illnesses. These early experiences also […]