Motor neurone disease


Improving our understanding of the causes of MND



The effects of MND vary greatly from person to person. MND may appear initially as a tingling or weakness in the hands and feet. Some people begin to stumble and can no longer hold objects in their hands easily. MND also affects the throat and tongue muscles, and some people with MND begin to slur their speech and have difficulty swallowing. In most cases, the disease eventually leads to widespread muscle wasting and weakness.

Common causes

The precise cause of MND and its disease process remains a complete mystery. Some researchers are looking into possible environmental triggers – such as exposure to toxins or electrical injury.

About our research

NeuRA is at the forefront of a new research field: the study of nerve excitability and its related disorders. We use novel physiological techniques to study the transmission of electrical signals through nerves so we can better understand why these signals fail in MND and related disorders.

Our hope is that with a better understanding of nerve physiology and function we may be able to provide new therapeutic strategies for neurological disorders such as MND. We are investigating the potential for new clinical tests to complement standard nerve conduction studies used in the diagnosis of MND.

Our research is intrinsically linked to local clinical services, particularly at the Prince of Wales Hospital Multidisciplinary MND Clinic located in Randwick, NSW. We also contribute to the Australian Motor Neurone Disease Registry.

What we have discovered

So far, our scientific discoveries have identified a number of potential new therapeutic targets. We were the lead Australian site for the GSK sponsored Study NOG112264 (a Phase II Study of Ozanezumab (GSK1223249) versus Placebo in the Treatment of MND).

Current projects

Patient-centered investigations

  • Cognition in MND
  • Brain Imaging in MND

Tissue based research

  • Neuropathology: these studies focus on understanding the internal cellular changes that occur in MND and how these relate to the structural imaging changes noted in life, and also to their genetic status. We are focussing on the TDP-43 protein and how it progresses through the brain in patients who have died at different stages of their disease. We are also assessing any changes in memory circuits and also in brain circuits important for movement and balance.
See what’s going on at NeuRA