Resilience defines the process that enables people to cope and positively adapt in the face of stress or misfortune, and enables them to better handle adversity or rebuild their lives after a catastrophe.
Being resilient does not mean a person has not experienced difficulty or distress or only remaining positive in the most dire of situations. Rather, resilient people are able to use their skills and strengths to cope and recover from problems or challenges, such as job loss, financial problems, illness, natural disasters or the death of a loved one.
There are several factors that are associated with resilience, including:
Importantly, these are skills that people can learn and develop for themselves.
In the past decade, resilience has emerged as a major theoretical and research topic. The focus of many studies has been to understand the role of our environment in resilience, as well as the psychological and behavioural factors that contribute to resilience in a person. In contrast, there is still a very limited understanding of the neuroscience or genetics of resilience. In particular, the brain networks that contributes to the resilience process, and how our genetics and environment influences these processes over time.
Mental health and wellbeing is not simply the absence of mental illness, yet we know very little about its underlying mechanisms in relative comparison. Dr Justine Gatt and Prof Peter Schofield, together with Prof Leanne Williams (Stanford University) are studying the genetics and neuroscience of resilience and wellbeing in a prospective cohort of 1,600 healthy adult twins. They have recently developed a new 26-item composite scale of wellbeing called COMPAS-W (Gatt et al., 2014, Psychiatry Res), with genetic modelling demonstrating a heritability estimate of 48% for total wellbeing. Multivariate modelling further suggested common genetic factors contributed to wellbeing and its subcomponents of composure, own-worth, mastery, positivity, achievement and satisfaction. Now they are aiming to understand the neuroscience of wellbeing and resilience, how different genes and environments modulate pathways to mental health, and how e-health tools can promote resilience against life stressors.
In Australia alone, 250,000 people are affected by bipolar disorder. Current treatments are highly variable for the severe and debilitating psychiatric condition and the specific genetic causes have remained largely obscure. Bipolar disorder is most commonly treated with lithium, but this is only effective for 30% of patients. Unlocking the genetic code of bipolar disorder and using pharmacogenomics studies to […]