Stress-related psychopathology

HEALTH INFORMATION

Stress and common biological mechanisms of psychotic and mood disorders

WHAT WE KNOW

Psychotic disorders (e.g., schizophrenia, schizoaffective disorder) and mood disorders (e.g., bipolar disorder, major depression) are known to share genetic vulnerabilities and environmental risk factors that affect brain function and cognition. Our multidisciplinary approach to understanding the stress-related neurobiology of these severe and disabling psychiatric conditions sees collaboration among experts in cognition, neuroimaging, genetics, and bioinformatics working together on a number of specific projects which are listed below according to funding received.

OUR LATEST RESEARCH

Imaging Genetics in Psychosis Study

The Imaging-Genetics in Psychosis study aims to determine common stress-related pathology among schizophrenia and bipolar disorder patients, in association with shared genetic vulnerabilities, cognitive deficits, and brain phenotypes.

Epistatic genetic effects on brain structure in schizophrenia

This project uses data from the Australian Schizophrenia Research Bank to determine interactive genetic effects on brain structure and cognition in schizophrenia.

Epigenetic and childhood trauma in psychotic and mood disorder

This project examines epigenetic (methylation) markers of childhood trauma in schizophrenia and bipolar disorder patients.

Childhood trauma and inflammatory markers

This project examines immune and stress response markers in association with epigenetic markers and brain structure/function in psychotic disorders.

What else is happening in Stress-related psychopathology research at NeuRA?

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