Stress-related psychopathology

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Stress and common biological mechanisms of psychotic and mood disorders

WHAT WE KNOW

Psychotic disorders (e.g., schizophrenia, schizoaffective disorder) and mood disorders (e.g., bipolar disorder, major depression) are known to share genetic vulnerabilities and environmental risk factors that affect brain function and cognition. Our multidisciplinary approach to understanding the stress-related neurobiology of these severe and disabling psychiatric conditions sees collaboration among experts in cognition, neuroimaging, genetics, and bioinformatics working together on a number of specific projects which are listed below according to funding received.

OUR LATEST RESEARCH

Imaging Genetics in Psychosis Study


OLIVER WATKEYS, YANN QUIDE, PROFESSOR MELISSA GREEN

The Imaging-Genetics in Psychosis study aims to determine common stress-related pathology among schizophrenia and bipolar disorder patients, in association with shared genetic vulnerabilities, cognitive deficits, and brain phenotypes.

Epistatic genetic effects on brain structure in schizophrenia


PROFESSOR MELISSA GREEN, DR KRISTIN LAURENS, PROF VAUGHAN CARR

This project uses data from the Australian Schizophrenia Research Bank to determine interactive genetic effects on brain structure and cognition in schizophrenia.

Epigenetic and childhood trauma in psychotic and mood disorder


YANN QUIDE, PROFESSOR MELISSA GREEN, DR JAN FULLERTON, PROFESSOR PETER SCHOFIELD AO

This project examines epigenetic (methylation) markers of childhood trauma in schizophrenia and bipolar disorder patients.

Childhood trauma and inflammatory markers


YANN QUIDE, PROFESSOR MELISSA GREEN

This project examines immune and stress response markers in association with epigenetic markers and brain structure/function in psychotic disorders.

TEAM LEADERS IN STRESS-RELATED PSYCHOPATHOLOGY

PROFESSOR MELISSA GREEN Conjoint Principle Research Scientist, NeuRA

What else is happening in Stress-related psychopathology research at NeuRA?

FEEL THE BUZZ IN THE AIR? US TOO.

The importance of medical research - Professor Peter Schofield AO

On August 11 2019, 54 people took on the City2Surf for Neuroscience Research Australia (NeuRA). The event is the world’s largest fun run with 80,000 participants taking on the 14km course, which stretches from Hyde Park in central Sydney to the iconic Bondi Beach. NeuRA thanks all of its fundraisers, who raised an incredible $30,903.  This funding will further NeuRA’s […]

Gabrielle Hunter
NeuRA BLOG: Team NeuRA at the City2Surf 2019

Entering the vital next phase in our fight against Alzheimer’s

‘Take care of all your memories… for you cannot relive them.’ The words of the American singer-songwriter Bob Dylan are so true… for you cannot relive them. For Amanda, a big turning point was the moment a test showed she carried the family’s early-onset Alzheimer’s gene. Would she see her 50th birthday? And would her most treasured family memories fade away like an old album of yellowing photos? Another turning point was her vow to take part in a large clinical trial in the hope of sparing her children’s lives, since they had a 50% chance of carrying the gene too. “Sign me up... I’m your girl”, she said. The day-by-day pressure on Amanda’s life in her Alzheimer’s clinical trial has been enormous. And her bravery and endurance only heighten the pressure on us to keep up – and intensify – the fight against the hideous disease of Alzheimer’s.
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NSW Falls Prevention Network Webinar: Patient Communication – enhancing safety and person centred care
Launch of the most comprehensive atlas of the human brainstem

Imaging Genetics in Psychosis Study

The Imaging-Genetics in Psychosis study aims to determine common stress-related pathology among schizophrenia and bipolar disorder patients, in association with shared genetic vulnerabilities, cognitive deficits, and brain phenotypes.
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