NeuRA Magazine #22

Feature Story

SYDNEY BRAIN BANK – A WORLD CLASS FACILITY

The Sydney Brain Bank has been operating since 2005 and has collected brain tissue from over 500 donors. The Sydney Brain Bank at NeuRA facilitates world-class research and breakthroughs in ageing and neurodegenerative disorders. Globally the Sydney Brain Bank supplies tissue to 30-40 research projects a year, with many of these projects a collaborative effort with external research institutions.

Processed with VSCO with a6 preset

Led by Dr Claire Shepherd, recently appointed to position of Director of the Sydney Brain Bank, the team has developed a new method which will allow them to characterise one of the key pathologies underlying Alzheimer’s disease using a simpler, cost effective and less labour-intensive method without compromising on the quality and sensitivity of the diagnosis.

Says Dr Shepherd, “At the Sydney Brain Bank, we collect, characterise and store the brain tissue from individuals that have died from ageing or neurodegenerative disorders so that we can facilitate medical research.”
“This new method will be advantageous because post-mortem human brain research takes a lot of time and money to do well – we undertake a comprehensive screen of every brain we collect. Doing this more cost effectively will allow us to collect more cases and facilitate more research into ageing and neurodegenerative disorders,” says Dr Shepherd.

At the Sydney Brain Bank, working with a large number of clinical research programs means the majority of donors have been involved in longitudinal clinical research studies. This data allows researchers to understand the relationship between someone’s clinical symptoms in life and the pathology in their brains at death.

There is currently no definitive diagnosis for these disorders in life. The Sydney Brain Bank at NeuRA uses research diagnostic criteria to characterise the brain changes and identify the specific neurodegenerative disease they were suffering from.

During 2017, Dr Claire Shepherd travelled to the UK to visit several British Brain Banks and to work with their researchers to understand their processes and share ideas and techniques.

By working with international researchers, NeuRA aims to strengthen and harness a more collaborative global approach between the various Brain Banks and to help address many research questions – working together is a more powerful way to go.
The Sydney Brain Bank is funded by NeuRA and our generous donors and receives no government support.

See what’s going on at NeuRA

FEEL THE BUZZ IN THE AIR? US TOO.

During three decades on Australian television, two simple words brought us to attention.

‘Hello daaaahling’. Outrageous, flamboyant, iconic – Jeanne Little captivated Australians everywhere with her unique style, cockatoo shrill voice and fashion sense. "Mum wasn't just the life of the party, she was the party.” Katie Little, Jeanne’s daughter remembers. This icon of Australian television brought a smile into Australian homes. Tragically, today Jeanne can't walk, talk or feed herself. She doesn't recognise anyone, with a random sound or laugh the only glimpse of who she truly is. Jeanne Little has Alzheimer's disease. The 1,000 Brains Study NeuRA is very excited to announce the 1,000 Brains Study, a ground-breaking research project to identify the elements in our brains that cause life-changing neurodegenerative diseases like Alzheimer’s, Parkinson’s and other dementias. This study will focus on the key unresolved question: why do some of us develop devastating neurodegenerative diseases, while others retain good brain health? The study will compare the genomes of people who have reached old age with healthy brains against the genomes of those who have died from neurodegenerative diseases, with post mortem examination of brain tissue taking place at NeuRA’s Sydney Brain Bank. More information on the study can be found here. Will you please support dementia research and the 1,000 Brains Study and help drive the future of genetics research in Australia? https://youtu.be/q7fTZIisgAY
APPEAL