NeuRA Magazine #22

Feature Story

SYDNEY BRAIN BANK – A WORLD CLASS FACILITY

The Sydney Brain Bank has been operating since 2005 and has collected brain tissue from over 500 donors. The Sydney Brain Bank at NeuRA facilitates world-class research and breakthroughs in ageing and neurodegenerative disorders. Globally the Sydney Brain Bank supplies tissue to 30-40 research projects a year, with many of these projects a collaborative effort with external research institutions.

Processed with VSCO with a6 preset

Led by Dr Claire Shepherd, recently appointed to position of Director of the Sydney Brain Bank, the team has developed a new method which will allow them to characterise one of the key pathologies underlying Alzheimer’s disease using a simpler, cost effective and less labour-intensive method without compromising on the quality and sensitivity of the diagnosis.

Says Dr Shepherd, “At the Sydney Brain Bank, we collect, characterise and store the brain tissue from individuals that have died from ageing or neurodegenerative disorders so that we can facilitate medical research.”
“This new method will be advantageous because post-mortem human brain research takes a lot of time and money to do well – we undertake a comprehensive screen of every brain we collect. Doing this more cost effectively will allow us to collect more cases and facilitate more research into ageing and neurodegenerative disorders,” says Dr Shepherd.

At the Sydney Brain Bank, working with a large number of clinical research programs means the majority of donors have been involved in longitudinal clinical research studies. This data allows researchers to understand the relationship between someone’s clinical symptoms in life and the pathology in their brains at death.

There is currently no definitive diagnosis for these disorders in life. The Sydney Brain Bank at NeuRA uses research diagnostic criteria to characterise the brain changes and identify the specific neurodegenerative disease they were suffering from.

During 2017, Dr Claire Shepherd travelled to the UK to visit several British Brain Banks and to work with their researchers to understand their processes and share ideas and techniques.

By working with international researchers, NeuRA aims to strengthen and harness a more collaborative global approach between the various Brain Banks and to help address many research questions – working together is a more powerful way to go.
The Sydney Brain Bank is funded by NeuRA and our generous donors and receives no government support.

See what’s going on at NeuRA

FEEL THE BUZZ IN THE AIR? US TOO.

The cold case of schizophrenia - broken wide open!

‘It is like they were miraculously healed!’’ Schizophrenia is diagnosed by clinical observation of behaviour and speech. This is why NeuRA researchers are working hard to understand the biological basis of the illness. Through hours of work and in collaboration with doctors and scientists here and around the world, NeuRA has made an amazing breakthrough. For the first time, researchers have discovered the presence of antibodies in the brains of people who lived with schizophrenia. Having found these antibodies, it has led NeuRA researchers to ask two questions. What are they doing there? What should we do about the antibodies– help or remove them? This is a key breakthrough. Imagine if we are treating schizophrenia all wrong! It is early days, but can you imagine the treatment implications if we’ve identified a new biological basis for the disease? It could completely change the way schizophrenia is managed, creating new treatments that will protect the brain. More than this, could we be on the verge of discovering a ‘curable’ form of schizophrenia? How you can help We are so grateful for your loyal support of schizophrenia research in Australia, and today I ask if you will consider a gift today. Or, to provide greater confidence, consider becoming a Discovery Partner by making a monthly commitment. We believe there is great potential to explore these findings. Will you help move today’s breakthrough into tomorrow’s cure? To read more about this breakthrough, click ‘read the full story’ below. You are also invited to read ‘Beth’s story’, whose sweet son Marcus lived with schizophrenia, by clicking here.
APPEAL