NeuRA Magazine #23

TIPS AND INFORMATION FROM DR JUSTINE GATT

With over 75% of the population reporting at least one or multiple major traumas in their lifetime, it is imperative that we understand why some people are more vulnerable and go on to develop mental illnesses like anxiety and depression, and why some are more adaptive and resilient.

In the field of mental health, most neuroscience research to date has focused on understanding what determines risk for mental illness and ways to treat it. In contrast, there are only a handful of studies which have started to look at the neuroscience of resilience and how to promote it.

Dr Justine Gatt and her research team at NeuRA, for the first time, will aim to identify the brain profiles which predict pathways towards resilience versus risk for mental illness over time. The team are currently doing this in a large sample of 1,600 adult twins ranging in age from 18 to 60 years. To start with, we have developed the first composite scale of wellbeing called the COMPAS-W which provides a combined measure of both subjective and psychological wellbeing.

The researchers are keen to test this measure in predicting patterns of resilience over time. To assist with this, Dr Gatt was recently successful in obtaining NHMRC funding to retest the twin sample 8 years after their initial characterisation. This study will be the first of its kind to show the neuroscience of longitudinal patterns of resilience (or risk) across adulthood. Beyond the current study in adults, the team is planning to take these studies to adolescents and children. They have already conducted a pilot study in 200 patients, looking at the promotion of optimal mental health and resilience as a global health priority. They have found some interesting patterns showing differences in levels of wellbeing across different cultures, and how different types of trauma exposure may modulate this process.

Childhood is a crucial period of personal and physical development, and a child’s brain is particularly vulnerable to the impact of different life experiences – both good and bad. It is therefore critical that we understand how trauma may impact the brain differently during different stages of development, and how optimal resilience can be promoted at different ages.

Grab a list of Dr Gatt’s Resilience tips HERE

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FEEL THE BUZZ IN THE AIR? US TOO.

During three decades on Australian television, two simple words brought us to attention.

‘Hello daaaahling’. Outrageous, flamboyant, iconic – Jeanne Little captivated Australians everywhere with her unique style, cockatoo shrill voice and fashion sense. "Mum wasn't just the life of the party, she was the party.” Katie Little, Jeanne’s daughter remembers. This icon of Australian television brought a smile into Australian homes. Tragically, today Jeanne can't walk, talk or feed herself. She doesn't recognise anyone, with a random sound or laugh the only glimpse of who she truly is. Jeanne Little has Alzheimer's disease. The 1,000 Brains Study NeuRA is very excited to announce the 1,000 Brains Study, a ground-breaking research project to identify the elements in our brains that cause life-changing neurodegenerative diseases like Alzheimer’s, Parkinson’s and other dementias. This study will focus on the key unresolved question: why do some of us develop devastating neurodegenerative diseases, while others retain good brain health? The study will compare the genomes of people who have reached old age with healthy brains against the genomes of those who have died from neurodegenerative diseases, with post mortem examination of brain tissue taking place at NeuRA’s Sydney Brain Bank. More information on the study can be found here. Will you please support dementia research and the 1,000 Brains Study and help drive the future of genetics research in Australia? https://youtu.be/q7fTZIisgAY
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