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β-Hydroxybutyrate metabolism in the brain

Although the contribution of the ketone body β-hydroxybutyrate to energy metabolism in the healthy brain is minimal, it is an interesting metabolite which is not only oxidised but also has other direct and collateral effects which make it a molecule of interest for therapeutic purposes. These effects may include metabolic, anti-inflammatory and anti-oxidant effects as well as roles in the treatment of neurodegenerative disorders and epilepsy. This project is investigating the role of β-hydroxybutyrate in the brain, both at the basic science level and also its interactions in disease models.