Biological basis of episodic memory
Functional and biological correlates of associative memory
Our ability to create and retrieve specific memories is dependent upon a number of discrete cognitive processes allowing us to create associations between different types of information. These processes are collectively called associative memory. Recent evidence suggests that brain structures within the medial temporal lobe are crucial for different types of associative memory. This project utilises different tasks of associative memory in combination with structural and functional magnetic resonance imaging techniques to investigate the neural correlates of associative memory processes. The goal of this research is to increase our understanding of the contributions of the medial temporal lobe contribute to these processes.
Contributions of prefrontal cortices to episodic memory
Episodic memory refers to our ability to remember events that are located in a particular time and place, for example where you left your car keys, or recalling your first day at school. The importance of the medial temporal lobes (MTL) for forming and retrieving episodic memories is well established, however, less is known regarding the role of the prefrontal cortex (PFC) or the possible interaction between these brain regions. This project investigates episodic memory disruption in frontotemporal dementia, a neurodegenerative disorder affecting both temporal and prefrontal brain regions selectively, providing us with a unique model to investigate the specialised roles of the MTL and PFC in episodic memory and how these systems interact.