Pastries being weighed on a scale

Eating and metabolic changes in frontotemporal dementia and motor neurone disease

It is well recognised that patients with FTD have changes in appetite control and food preference towards sweet food. They also become very rigid in their food choices. In collaboration with Prof Sadaf Farooqi in Cambridge, UK we have been investigating these changes using a test meal approach in conjunction with measures of metabolism. We have also looked at the impact of overeating on body weight, cholesterol and insulin levels and relating all of these changes to regions of brain pathology as demonstrated by MRI imaging. We are now extending these studies to investigate patients with motor neurone disease and with Alzheimer’s as well as those at risk of genetic FTD.