MRI of brain with coloured areas

Magnetic resonance elastography

We have developed new MRI methods to measure the mechanical properties of soft tissues (Magnetic Resonance Elastography or MRE). So far, MRE has been used to measure the stiffness of the brain, muscles and other tissues. We continue to develop new approaches, such as combining elastography with Diffusion Tensor Imaging to measure the anisotropic properties of muscles and brain white matter tracts, and how this changes in muscle and neurological disorders. We have discovered that there are changes in tissue stiffness in hydrocephalus (a brain disorder), obstructive sleep apnoea, and degenerative muscle conditions (muscular dystrophy). We are currently working on new methods to measure tissue properties under loading. Honours and PhD projects are available both for developing new methods (to suit engineers and physicists) or in applying these techniques to study clinical disorders.