This research investigates the molecular indices of blood-brain barrier alterations in the brains of people with schizophrenia compared to healthy adults. These changes are also considered in the context of elevated inflammation, which has been found in a subset of people with schizophrenia.
We know that having high blood pressure increases the chance that we will develop dementia and cognitive decline as we grow older but we are still trying to understand whether using blood pressure lowering treatments (antihypertensives) can help to prevent this. To explore the relationship between blood pressure, blood pressure lowering and cognition we will combine global data from the highest quality placebo-controlled trials of antihypertensive drugs. This project will deliver knowledge and targeted clinical recommendations for antihypertensive use to support reduction of dementia risk.
This project is underway and is recruiting 125 adults aged 60-70 from multicultural backgrounds. The interviews are conducted online on zoom and standardised surveys as well as qualitative questions are administered. A Dietary Inflammatory Index will be calculated via a collaboration with the University of South Carolina.