This project focuses on inflammation in the risk of developing schizophrenia phenotypes and worsening neuropathology. The research is investigating whether neuroinflammatory biotypes exacerbate deficits in molecular indices important for inhibitory interneurons in two regions of the frontal cortex in schizophrenia cases
Studying the molecular basis of raloxifene (a SERM) modulation of dopamine signalling in schizophrenia, which uses a maternal immune activation rodent model of schizophrenia to better understand how raloxifene brings about its effects.
Commencing in 2021, this open labelled pilot randomised controlled trial will look at the impact of fibre and antioxidants on frailty, inflammation and the microbiome.
This project is underway and is recruiting 125 adults aged 60-70 from multicultural backgrounds. The interviews are conducted online on zoom and standardised surveys as well as qualitative questions are administered. A Dietary Inflammatory Index will be calculated via a collaboration with the University of South Carolina.