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CNS reservoirs in NeuroHIV

This project is dedicated to the identification and quantification of HIV reservoirs biomarkers in the Central Nervous System. When HIV-infected patients are on combined antiretroviral treatment and have suppressed viral replication, about 20%-30% still experience neurocognitive difficulties. Because the patients HIV is under control, the cause of these difficulties is not known. One strong possibility is that the CNS acts a reservoir for HIV and that this process causes chronic neuroinflammation, which in turn underlies cognitive problems. This is a NHMRC project grant (01/2016-12/2019) in collaboration with CIA Prof Bruce Brew at St Vincent’s Hospital/UNSW and where Dr Lucette Cysique is chief investigator B, lead neuropsychologist and lead in neuroimaging.