brain training and fitness

Targeted cognitive training in persons with HIV-associated Neurocognitive Disorder: a Pilot study in association with St Vincent’s Hospital, Sydney

The primary aim of the current study is to assess if computerised cognitive training improves neurocognitive functions in persons with HIV-associated Neurocognitive Disorder. We will also establish what is the optimal intensity and schedule of the cognitive training program.

We are currently enrolling

  • Persons diagnosed with HIV-associated Neurocognitive Disorder (HAND) who are otherwise clinically stable:
  • With an undetectable plasma viral load, and;
  • Stable on combined Antiretroviral treatment for at least 6 months

If you decide to take part in this study, the following will happen:

  • Consent form will be signed prior to any study assessments being performed
  • We will conduct a final eligibility check and if passed, you will be asked to complete a 1-hour session at St Vincent’s Hospital or NeuRA which will include a short computerised cognitive test (30 minutes). On this occasion we will also collect basic demographic information (age, gender etc). Next, we will go with you over the cognitive training program which is computerised and internet-based (30 minutes).
  • Then for the next 2 weeks, we will ask you to complete 1 hour session of cognitive training, 3 times a week at home when it is convenient for you.
  • For the second at St Vincent’s Hospital or NeuRA, we will ask you to complete again the short computerised cognitive test (30 minutes). And finally, we will record your feedback on the cognitive training using a questionnaire we have developed as well as any comments you may think is relevant.
  • Then for the next 2 months and 2 weeks, we will ask you to continue the cognitive training taking into account any of the feedback that was discussed at the two-weeks follow-up visit.
  • For the third and final at St Vincent’s Hospital or NeuRA, we will ask you to complete a final time the short computerised cognitive test (30 minutes). And finally, we will again record your feedback on the cognitive training using a questionnaire we have developed as well as any comments you may think is relevant
  • The research time participation is expected to be a maximum 3 months. Visits will be booked at a convenient time for you.
  • The visits will take place at St Vincent’s Hospital Neurology Department (Darlinghurst, NSW) or at or NeuRA (Randwick, NSW).

There are no additional costs associated with participating in this study, nor will you be paid. All tests required as part of the study will be provided to you free of charge. However, you may be reimbursed for any reasonable travel, parking, meals and other expenses associated with the 3 study visits.

  • We do request that you do not complete the training at a time or just after you may have been drinking or using recreational substances (even in moderation) as this may affect the results or the way you use the program
  • Otherwise you should not change any of your everyday life activities, dietary habits and other treatment in accordance with your physician’s instructions

You are able to withdraw at any time, as your participation is entirely voluntary. In the case you withdraw this will not affect your treatment and care at Sydney St Vincent’s Hospital or any potential future research participation at NeuRA.

For further information or to participate, contact:

Lucette A Cysique, PhD

Office Ph: +61 2 9399 1880

Mobile Ph: (+61) (0)431 576 710 (text preferred)

Email: l.cysique@neura.edu.au

Alternate emails: lcysique@unsw.edu.au; lucette.cysique@svha.org.au