The Dementia rIsk REduCTion (DIRECT) collaboration

We know that having high blood pressure increases the chance that we will develop dementia and cognitive decline as we grow older but we are still trying to understand whether using blood pressure-lowering treatments (antihypertensives) can help to prevent this. To explore the relationship between blood pressure, blood pressure lowering and cognition we will combine global data from the highest quality placebo-controlled trials of antihypertensive drugs. Working across three institutions, The George Institute for Global Health, Neuroscience Research Australia and Imperial College London  this project will deliver knowledge and targeted clinical recommendations for antihypertensive use to support reduction of dementia risk.