Projects

Each tile includes a summary and discussion of the aims of current research projects at NeuRA.

If you’d like to be involved as a participant, please click here to find out about volunteering for research.

If you are a student and would like to conduct a similar project with one of our supervisors, click here to find out about studying at NeuRA.

Raloxifene treatment in Maternal Immune Activation model of Schizophrenia

Studying the molecular basis of raloxifene (a SERM) modulation of dopamine signalling in schizophrenia, which uses a maternal immune activation rodent model of schizophrenia to better understand how raloxifene brings about its effects.

AGReMA Project

Developing a Guideline for Reporting Mediation Analyses (AGReMA) in randomized trials and observational studies.

Can high dose of vitamin C boost recovery after balance organ injury?

We will address loss of balance, a pressing health-related issue that affects quality of life in ~5% of the population. Once the balance organ is injured or degrades with age, no treatments restore function. We have identified a nerve-pathway crucial for balance system adjustment & self-repair. The sensitivity of this pathway can be increased with vitamin C. We will determine if vitamin C treatment can improve recovery after balance loss and potentially translate to the clinic.

Genetic contributors, clinical course and pharmacogenomics of Bipolar Disorder

Bipolar Disorder is a severe and debilitating psychiatric condition, for which the clinical course is highly variable between individuals, and the specific genetic causes remain largely obscure. This landmark study aims to use state-of-the-art whole genome sequencing technology to address four key knowledge gaps:

Quantitative trait analysis of bipolar disorder

Genetic research into bipolar disorder traditionally uses strict categorical criteria to define a clinical diagnosis. However, it is common for relatives of individuals with bipolar to exhibit some evidence of mood disturbance, but not sufficient to meet the strict clinical criteria for a positive diagnosis. These individuals are correctly considered clinically unaffected, although they likely share some of the susceptibility genes underlying the disorder. Dr Fullerton has been examining the use of subclinical traits to identify individuals who share susceptibility genes in order to follow the pattern of genetic transmission of bipolar disorder through families more accurately.

Longitudinal neural trajectories of vulnerability versus resilience in adult twins

Dr Gatt is leading a project that focuses on identifying the longitudinal neural trajectories of vulnerability versus resilience in adult twins. This project involves a 9-year and 11-year follow-up of our adult twin cohort from the TWIN-E Emotional Wellbeing Study.