Projects

Each tile includes a summary and discussion of the aims of current research projects at NeuRA.

If you’d like to be involved as a participant, please click here to find out about volunteering for research.

If you are a student and would like to conduct a similar project with one of our supervisors, click here to find out about studying at NeuRA.

Medicines for Back Pain

Medicines are a common treatment for back pain. The aim of this program of research is to improve our understanding of the clinical effects of medicines. Several studies constitute this program. 
 
Studies: 
1. A scoping review of analgesic medicines for chronic low back pain
The objective of this study is to identify the available clinical trials of medicines for chronic low back pain.  
This information will contribute to the methodology of Study 3. 
 
2. Evaluation of the impact of unpublished data from clinical trial registries on the effects of medicines for low back pain. 
The objective of this study is to evaluate whether there is a difference between clinical trial data that are published and those that are not published. 
This information will contribute to the methodology of Study 3. 
 
3. Paracetamol, NSAIDs and opioid analgesics for chronic low back pain: a network meta-analysis. 
The objective of this study is to produce information about the clinical effects of available analgesic medicines for chronic low back pain. This information will be available in a Cochrane review to assist clinical prescription of medicines.

Exploring the electrophysiology and heritability of wellbeing and resilience

The majority of adults without a mental illness still experience poor mental health, indicating a need for a better understanding of what separates mental wellness from mental illness. One way of exploring what separates those with good mental health from those with poor mental health is to use electroencephalography (EEG) to explore differences in brain activity within the healthy population. Previous research has shown that EEG measures differ between clinical groups and healthy participants, suggesting that these measures are useful indicators of mental functioning.

Miranda Chilver’s current project aims to examine how different EEG measures relate to each other and to test if they can be used to predict mental wellbeing. Furthermore, she hopes to distinguish between EEG markers of symptoms including depression and anxiety, and markers of positive symptoms of wellbeing to better understand how wellbeing can exist independently of mental illness. This will be done by obtaining measures of wellbeing and depression and anxiety symptoms using the COMPAS-W and DASS-42 questionnaires, respectively.

Because EEG measures and mental wellbeing are both impacted by genetics as well as the environment, Miranda will also be testing whether the links found between EEG activity and Wellbeing are driven primarily by heritable or by environmental factors. This information will inform the development of future interventions that will aim to improve wellbeing in the general population.

To achieve these goals, the project will assess the relationship between EEG activity and wellbeing, and between EEG and depression and anxiety symptoms to first test whether there is an association between EEG and mental health. Second, the heritability of the EEG, wellbeing, depression, and anxiety will be assessed to determine the extent to which these variables are explained through heritable or environmental factors. Finally, a model assessing the overlap between the heritable versus environmental contributions to each measure will be developed to assess whether genetics or environment drive the relationship between EEG and mental health.

This project is based on a sample of over 400 healthy adult twins from the Australian TWIN-E study of resilience led by Dr Justine Gatt. This research will pave the way for improved mental health interventions based on individual needs.

Genes and wellbeing; how are they connected?

Despite numerous research into the genetics of psychiatric disorders, investigations regarding the molecular genetics of wellbeing and resilience and in general healthy functioning using new technologies and methods are still scarce. There is very little known about the genetic factors influencing our wellbeing and resilience. Only a few recent genome wide association studies successfully detected a number of genetic variants influencing wellbeing. However, these variants are only responsible for a very small proportion of wellbeing heritability and much more are still waiting to be discovered.

My research area is focused on understanding the role of genetics and environment in mental wellbeing and resilience; in particular, the role of genetic and epigenetic factors and how they interact with each other and the environment in predicting mental health.

We have at our disposal an amazing population of 1600 twins with psychological data including mental health and wellbeing questionnaires, including personality questionnaires and a specific composite wellbeing questionnaire developed by the Gatt group called COMPAS-W.  These twins also underwent a genetic analysis using PsychArray and their genotyping data is available. In addition, a portion of these twins have EEG and neuroimaging data (MRI, fMRI, DTI), which will allow us to further investigate the effect of genetic markers on these variables and how they interact to yield the end phenotype.

We have three main questions to answer in this project:

First, do genetic variations influence wellbeing in our twin cohort? Which genes? How and to what extent?

Second, do genetic variations influence the neurobiological markers measured by EEG, MRI, fMRI and DTI in the twin population?

Third, is there any connection or correlation between the genetic markers which influence wellbeing and those which influence the neurobiological markers? How much of these phenotypes are genetically correlated?

Functional magnetic resonance imaging correlates of wellbeing and resilience in healthy twins

Every aspect of our lives influences our state of wellbeing and in turn, our wellbeing greatly affects our lives and long-term health. Several studies have shown that wellbeing predicts increased longevity and healthy aging, resistance to infection, reduced risk for illness and mortality, personal growth and even learning. More recently, mental wellbeing has been positively associated with sustained attention, inhibition, cognitive flexibility, motor coordination and working memory. Additionally, major mental illnesses are usually associated with emotional and cognitive dysfunction, and neural networks involved in threat, reward, attention and cognitive control underscore some of the main processes of emotional and cognitive function. These networks are therefore likely to be central to mental wellbeing and resilience to stress. Although the link between wellbeing and health has been fairly well documented, knowledge of the neural mechanisms that underpin wellbeing and resilience are still lacking. Investigating the neuroscience of wellbeing is crucial to capture and promote mental and physical health in the general population.

 

Using the functional magnetic resonance imaging (fMRI) technique, the main objectives of this project are:

(1). To understand how the neural networks and autonomic responses that underpin emotional responses (e.g., to threat and reward) and cognitive control (e.g., working memory and inhibition) are associated with varying levels of wellbeing, resilience, emotional health status and other life outcomes;

(2). Whether change in neural networks predict change in wellbeing and resilience over time (longitudinal component); and

(3). To investigate how different genetic and environment factors may modulate these neural networks.

 

This PhD project will extend our understanding of wellbeing and its relationship with emotional processes and cognitive function. The results from this project will be valuable and robust as it will be based on a large sample of 270 twin participants scanned over time. Research on wellbeing and resilience has major implications for mental and physical health on the general population, and we hope that this project will greatly contribute to the advancement of mental health research.

Health literacy on falls in older people

An informed and engaged older adult who values health promotion, protection, and preparedness is vital to promote uptake and adherence to any health and fall prevention programs.

According to the Australian Bureau of Statistics, about 60 per cent of Australians (15-74 years old) have less than adequate levels of health literacy and only 6% of the population have high health literacy. Health literacy was also found to be lower in old age. The majority of Australians with inadequate health literacy were aged 65 to 74 years. Similarly, in another Australian survey, only 8% of 1454 older adults were aware that balance training can prevent falls, or that falls could be prevented at all. This is indicative of poor health literacy among older Australians related to fall risk and fall prevention. With the increasing complexity of health information and services, health literacy is an issue for older Australians. Health literacy may affect individuals’ understanding of health information and in turn influence their health decisions and uptake of health preventive interventions such as engaging in physical activities to prevent falls.

This project will address a crucial gap in empowering older adults to take care of their own health and increase the uptake and efficacy of evidence-based fall prevention programs. An informed and engaged older adult who values health promotion, protection, and preparedness is vital to promote uptake and adherence to any health and fall prevention programs.

Moving - thinking - feeling

Interrelationships between physical, cognitive and psychological function and falls.

Concomitant impairments in physical, psychological and cognitive function are common in old age. Our previous work has elucidated that addressing these impairments and their interplay are critical to minimize fall risk and achieve healthy ageing. The overall research objective of our ongoing research in this area is to develop a clearer understanding of inter-related underlying mechanisms of the effects across the triad of physical (frailty, balance), psychological (fear of falling, mood), cognitive (executive function, MCI, dementia) and neural (white matter integrity) impairments on falls and healthy ageing.