Digitally created image of brain in skull

ForeFront

RESEARCH CENTRE

About us

ForeFront provides a unique combination of clinical and laboratory-based research which together aim to unravel the mechanisms behind frontotemporal dementia (FTD) and motor neurone disease (MND) and help to develop effective treatments.

ForeFront comprises two government funded research groups across four themes:

FTD and MND NHMRC Program grant

  1. Neuropathology
  2. Animal modelling and cellular/molecular biology
  3. Neurological research clinics

Memory node of the ARC Centre of Excellence in Cognition and its Disorders

  1. Cognition and neuroimaging

Who’s involved?

Neuropathology

What regions and cell types are vulnerable? What proteins are affected?

Prof Glenda Halliday and Professor Jillian Kril

Animal modelling and cellular/molecular biology

What proteins are toxic and how do they cause pathogenesis? What cells are vulnerability and how can we prevent this?
Professor Jürgen Götz and Assoc. Professor Lars Ittner

Clinical

How does the disease spread through the brain? How can we develop identification tools and test symptomatic treatments?

Prof John Hodges and Prof Matthew Kiernan

Cognition and neuroimaging

What brain functions are impaired? What brain areas are impaired and which functions do they subserve?

Assoc Professor Olivier Piguet and Dr Michael Hornberger

For more information on the clinical aspects of these disease click here

For more information on the laboratory-based research on these diseases click here

 

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FEEL THE BUZZ IN THE AIR? US TOO.

'I've got the best job for you dad. Your shaky arm will be perfect for it!'

Children… honest and insightful. Their innocence warms the heart. But what words do you use to explain to a child that daddy has an incurable brain disease? What words tell them that in time he may not be able to play football in the park, let alone feed himself? What words help them understand that in the later stages, dementia may also strike? Aged just 36, this was the reality that faced Steve Hartley. Parkinson's disease didn't care he was a fit, healthy, a young dad and devoted husband. It also didn't seem to care his family had no history of it. The key to defeating Parkinson's disease is early intervention, and thanks to a global research team, led by NeuRA, we're pleased to announce that early intervention may be possible. Your support, alongside national and international foundations Shake it Up Australia and the Michael J Fox Foundation, researchers have discovered that a special protein, found in people with a family history of the disease increases prior to Parkinson’s symptoms developing. This is an incredible step forward, because it means that drug therapies, aimed at blocking the increase in the protein, can be administered much earlier – even before symptoms strike. The next step is to understand when to give the drug therapies and which people will most benefit from it. But we need your help. A gift today will support vital research and in time help medical professionals around the world treat Parkinson’s disease sooner, with much better health outcomes. Thank you, in advance, for your support.  
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