Digitally created image of brain in skull

ForeFront

RESEARCH CENTRE

Forefront operates two research clinics with the aim of better understanding frontotemporal dementia (FTD) and motor neurone (MND) syndromes. These clinics allow translation of our research into clinical practice.
1. Our Clinics

FRONTIER is the only dedicated FTD clinic in Australia. It was established by Prof John Hodges in 2007 and receives 80-100 new patients annually for comprehensive research evaluation. Each patient is followed at 6-12 month intervals using clinic or home visits and/or questionnaires. Serial blood samples are collected for the establishment of cell lines, and DNA and serum extraction.

Read more…

2. Cognition and neuroimaging

Assoc Prof Olivier Piquet has 10 years experience in clinical research combined with 20 years experience as a clinical neuropsychologist. Dr Michael Hornberger is an expert in imaging and interested in identifying the neural correlates of behavioural and cognitive symptoms in patients. They combine cognitive, imaging and neuropathological methods in their research.

A 3-Tesla Philips scanner is available at NeuRA to undertake a full range of grey and white matter tract imaging.

We aim to find out which functions of the brain and brain areas are first affected by FTD and MND, and improve clinical diagnostic procedures.

How to get involved?

3. Biospecimens

In order to develop effective interventions for people with FTD, tests to identify the type of cellular changes occurring in the brain need to be developed, especially for those with the initial symptoms of FTD and MND where treatments would be of the greatest benefit. We aim to achieve this by using biospecimens from DNA, blood and brain donations.

Ultimately our goal is to find a cure for these devastating conditions. Our current research goal is to develop an easily identifiable biological marker (a biomarker) that indicates the type of cellular changes occurring in the brain of each patient with FTD. In order to do this, we will be screening blood from people with FTD and MND for a broad array of cellular markers such as proteins that accumulate in the brain, and other molecules associated with cell degeneration. To develop these biomarkers, it is essential to use brain tissue.

How can I donate my brain?

See what’s going on at NeuRA

FEEL THE BUZZ IN THE AIR? US TOO.

ReacStep – novel balance training programs to prevent falls in older adults

The ReacStep study is investigating the short-term effects of two balance training programs (i.e. reactive balance training and conventional balance training) on balance recovery from slips and trips in older adults. These programs are designed from evidence-based research and offer a challenging and unique experience to improving balance. The ReacStep team are calling on volunteers who: are aged 65 and over living independently in the Sydney metropolitan community can walk 500m comfortably with mobility aids or rest have not been advised by a medical practitioner not to exercise have no neurological conditions (e.g. Parkinson’s Disease, multiple sclerosis, Alzheimer’s, dementia, etc.) have no history or lower limb, pelvic or vertebral fracture(s) and/or lower limb joint replacement(s) in the past 6 months have no other existing conditions that may prevent them from exercising (e.g. injury, pain, fatigue, etc.) Eligible volunteers will be subjected to a health and safety screening before they are enrolled and randomly allocated into one of the two groups. Both groups will undertake a 3-week training program with an exercise physiologist, at NeuRA (i.e. in Randwick) as well as a balance recovery assessment at the 4-week time point. Reactive balance training involves intentionally stepping on a sliding tile, stepping over obstacles, trigger-release recovery as well as strength training. Participants will be wearing a full-body safety harness to ensure safety. Conventional balance training involves keeping balance in varying foot positions (i.e. feet together, in tandem or on one leg) whilst performing secondary tasks such as throwing a ball, card sorting, solving a maze or playing computer games. For more detailed information, read the Participant Information Statement and watch the video below. To get involved or to register your interest, click HERE. For all other queries, please contact the ReacStep Team on 02 9399 1002 or reacstep-study@neura.edu.au. HC210350 https://www.youtube.com/watch?v=ym0zlwqhXmw
PROJECT