Digitally created image of brain in skull

ForeFront

RESEARCH CENTRE

Forefront operates two research clinics with the aim of better understanding frontotemporal dementia (FTD) and motor neurone (MND) syndromes. These clinics allow translation of our research into clinical practice.
1. Our Clinics

FRONTIER is the only dedicated FTD clinic in Australia. It was established by Prof John Hodges in 2007 and receives 80-100 new patients annually for comprehensive research evaluation. Each patient is followed at 6-12 month intervals using clinic or home visits and/or questionnaires. Serial blood samples are collected for the establishment of cell lines, and DNA and serum extraction.

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2. Cognition and neuroimaging

Assoc Prof Olivier Piquet has 10 years experience in clinical research combined with 20 years experience as a clinical neuropsychologist. Dr Michael Hornberger is an expert in imaging and interested in identifying the neural correlates of behavioural and cognitive symptoms in patients. They combine cognitive, imaging and neuropathological methods in their research.

A 3-Tesla Philips scanner is available at NeuRA to undertake a full range of grey and white matter tract imaging.

We aim to find out which functions of the brain and brain areas are first affected by FTD and MND, and improve clinical diagnostic procedures.

How to get involved?

3. Biospecimens

In order to develop effective interventions for people with FTD, tests to identify the type of cellular changes occurring in the brain need to be developed, especially for those with the initial symptoms of FTD and MND where treatments would be of the greatest benefit. We aim to achieve this by using biospecimens from DNA, blood and brain donations.

Ultimately our goal is to find a cure for these devastating conditions. Our current research goal is to develop an easily identifiable biological marker (a biomarker) that indicates the type of cellular changes occurring in the brain of each patient with FTD. In order to do this, we will be screening blood from people with FTD and MND for a broad array of cellular markers such as proteins that accumulate in the brain, and other molecules associated with cell degeneration. To develop these biomarkers, it is essential to use brain tissue.

How can I donate my brain?

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FEEL THE BUZZ IN THE AIR? US TOO.

Ten siblings. One third live (or have passed away) with dementia.

The scourge of dementia runs deep in Lorna Clement's family. Of the eleven children her dear parents raised, four live (or have passed away) with complications of the disease. Her mother also died of Alzheimer's disease, bringing the family total to five. This is the mystery of dementia - One family, with two very different ageing outcomes. You will have read that lifestyle is an important factor in reducing the risk of dementia. We also know diet is a key factor, and an aspect that Dr Ruth Peter's is exploring at NeuRA. Along with leading teams delivering high profile evidence synthesis work in the area of dementia risk reduction, Dr Peters has a particular interest in hypertension (that is, high blood pressure) and in the treatment of hypertension in older adults. “We have known for a while that treating high blood pressure reduces the risk of cardiovascular disease and stroke, but it is becoming clearer that controlling blood pressure may also help to reduce the risk of cognitive decline and dementia. Now we need to know what the best blood pressure is to protect brain health.” You are invited to read more about Lorna's story and Dr Peter's work, by clicking 'Read the full story' below. Please support dementia research at NeuRA Will you consider a gift today to help Dr Peter's unlock the secrets of healthy ageing and reduce the risk of dementia? Research into ageing and dementia at NeuRA will arm doctors and other medical professionals with the tools they need to help prevent dementia in our communities. Thank you for your support.
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