Research participant's arm in a machine designed for motor impairment study

Motor Impairment

RESEARCH CENTRE

Opportunities

There are likely to be a number of new positions associated with the Program, some will become available as some of the clinical trials and associated laboratory studies begin.

As part of the Program we will train PhD and Honours students through University of New South Wales academic programs and those of other universities, and we will provide strong mentorship for postdoctoral researchers. As one element in the program is the breadth of research, from laboratory work to implementation of practice guidelines, we will offer deliberate exposure to a range of clinical and experimental work to train the next generation of medical researchers. The investigators will establish a strong interdisciplinary culture to maximise the outcomes from the work.

For more information on how to get involved with the program please contact Simon Gandevia (s.gandevia@neura.edu.au)

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Caress the Detail: A Comprehensive MRI Atlas of the in Vivo Human Brain

This project aims to deliver the most comprehensive, detailed and stereotaxically accurate MRI atlas of the canonical human brain. In human neuroscience, researchers and clinicians almost always investigate images obtained from living individuals. Yet, there is no satisfactory MRI atlas of the human brain in vivo or post-mortem. There are some population-based atlases, which valiantly solve a number of problems, but they fail to address major needs. Most problematically, they segment only a small number of brain structures, typically about 50, and they are of limited value for the interpretation of a single subject/patient. In contrast to population-based approaches, the present project will investigate normal, living subjects in detail. We aim to define approximately 800 structures, as in the histological atlas of Mai, Majtanik and Paxinos (2016), and, thus, provide a “gold standard” for science and clinical practice. We will do this by obtaining high-resolution MRI at 3T and 7T of twelve subjects through a collaboration with Markus Barth from the Centre for Advanced Imaging at the University of Queensland (UQ). The limited number of subjects will allow us to image each for longer periods, obtaining higher resolution and contrast, and to invest the required time to produce unprecedented detail in segmentation. We will produce an electronic atlas for interpreting MR images, both as a tablet application and as an online web service. The tablet application will provide a convenient and powerful exegesis of brain anatomy for researchers and clinicians. The open access web service will additionally provide images, segmentation and anatomical templates to be used with most common MR-analysis packages (e.g., SPM, FSL, MINC, BrainVoyager). This will be hosted in collaboration with UQ, supporting and complementing their population-based atlas.
PROJECT