Research participant's arm in a machine designed for motor impairment study

Motor Impairment


Selected publications

Professor Simon GANDEVIA
Gandevia SC. (1985). Illusory movements produced by electrical stimulation of low-threshold muscle afferents from the hand. Brain 108, 965-981.
Colebatch JG & Gandevia SC. (1989). The distribution of muscular weakness in upper motor neuron lesions affecting the arm. Brain 112, 749-763.
Gandevia SC, Macefield G, Burke D & McKenzie DK. (1990). Voluntary activation of human motor axons in the absence of muscle afferent feedback. Brain 113, 1563-1581.
Gandevia SC, Killian K, McKenzie DK, Crawford M, Allen GM, Gorman RB & Hales JP. (1993). Respiratory sensations, cardiovascular control, kinaesthesia and transcranial stimulation during paralysis in humans. J Physiol 470, 85-107 (with Lancet commentary)
Kilbreath SL & Gandevia SC. (1994). Limited independent flexion of the thumb and fingers in human subjects. J Physiol 479, 487-497.
Gandevia SC. (2001). Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 81, 1725-1789 (cited > 900 times).
Gandevia SC, Smith JL, Crawford M, Proske U & Taylor JL. (2006). Motor commands contribute to human position sense. J Physiol 571, 703-710.
Taylor JL & Gandevia SC. (2008). A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions. J Appl Physiol 104, 542-550.
Herbert RD, Clarke J, Kwah LK, Diong J, Martin J, Clarke EC, Bilston LE & Gandevia SC. (2011). In vivo passive mechanical behaviour of muscle fascicles and tendons in human gastrocnemius. J Physiol 589, 5257-5267.
Proske U & Gandevia SC. (2012). The proprioceptive senses: their roles in signalling body shape, body position and movement, and muscle force. Physiol Rev, 81, 1725-1789.

Professor Stephen LORD
Lord SR, Ward JA, Williams P, Anstey K. Physiological factors associated with falls in older community-dwelling women. J Am Geriatr Soc 1994;42:1110-17.
Nguyen TV, Sambrook, PN, Kelly PJ, Jones G, Lord SR et al. Prediction of osteoporotic fractures by postural stability and bone density. BMJ 1993;307:1111-15.
Lord SR et al. The effect of a 12 month exercise program on balance, strength and falls in older women. J Am Geriatr Soc 1995;43:1198-1206.
Day L, Fildes B, Gordon I, Fitzharris M, Flamer H, Lord S. Randomised factorial trial of falls prevention among older people living in their own homes. BMJ 2002;325:128-131.
Menz HB, Lord SR et al. Age-related differences in walking stability. Age and Ageing 2003;32:137-42.
Lord SR et al. Differing risk factors for falls in nursing home and intermediate-care residents who can and cannot stand unaided. J Am Geriatr Soc 2003;51:1645-50.
Sherrington C, Whitney JC, Lord SR et al. Effective approaches to exercise in the prevention of falls–a systematic review and meta-analysis. J Am Geriatr Soc 2008;56:2234-43.
Latt MD, Lord SR et al. Clinical and physiological assessments for elucidating falls risk in Parkinson’s disease. Movement Disorders 2009;24:1280-9.
Delbaere K, Lord SR et al. Determinants of disparities between perceived and actual risk of falls in community living older people. BMJ 2010;341:c4165.
Haran MJ, Lord SR et al. The effect on falls of providing single lens distance vision glasses to multifocal glasses wearers. BMJ 2010;340:c2265.
Delbaere K, Lord SR et al. A multifactorial approach for understanding fall risk in older people. J Am Geriatr Soc 2010;58:1679-85.
Zheng JJ, Delbaere K, Close JC, Sachdev P, Lord SR. Impact of white matter lesions on physical functioning and fall risk in older people: a systematic review. Stroke 2011;42:2086-2090.
Zheng JJ, Lord SR et al. Brain white matter hyperintensities, executive dysfunction, instability and falls in older people: a prospective cohort study. J Gerontol: Med Sci 2012;67:1085-1091.
Schoene DS, Lord SR, Delbaere K, Severino C, Davies TA, Smith ST. A randomized controlled pilot study of home-based step training in older people using videogame technology. PLoS ONE 8(3): e57734. doi:10.1371/journal.pone.0057734.
Taylor M, Delbaere K, Lord SR, Mikolaizak AS, Brodaty H, Close JCT. Neuropsychological, physical and functional mobility measures associated with falls in cognitively impaired older adults. Journal of Gerontology: Medical Science. 2013; doi: 10.1093/gerona/glt166.
Paul SS, Sherrington C, Canning CG, Fung VSC, Close JCT, Lord SR. The relative contribution of physical and cognitive fall risk factors in people with Parkinson’s disease: a large prospective cohort study. Neurorehabilitation and Neural Repair. In Press 31/8/2013.
Hoang P, Cameron MH, Gandevia SC, Lord SR. Neuropsychological, balance and mobility risk factors for falls in people with multiple sclerosis: a prospective cohort study. Archives of Physical Medicine and Rehabilitation. In Press 24/9/2013.

Professor Rob HERBERT
Ferreira ML, Herbert RD, Crowther MJ, Verhagen A, Sutton AJ. When is a further clinical trial justified? BMJ 2012;345: e5913.
Broderick CR, Herbert RD, Latimer J, Barnes C, Curtin JA, Mathieu E, Monagle P, Brown SA. Association between physical activity and bleeding risk in children with haemophilia. JAMA 2012;308: 1452-1459.
Herbert RD, Clarke J, Kwah LK, Diong J, Martin J, Clarke EC, Bilston LE, Gandevia SC. In vivo passive mechanical behaviour of muscle fascicles and tendons in human gastrocnemius muscle tendon units. J Physiol 2011;589:5257-5267.
Tian M, Hoang PD, Gandevia SC, Herbert RD, Bilston LE. Viscous elements have little impact on measured passive length-tension properties of human gastrocnemius muscle-tendon units in vivo. J Biomech 2011;44:1334-1339.
Herbert RD, Jamtvedt G, Mead J, Hagen KB. Practical Evidence-Based Physiotherapy. Oxford: Elsevier; 2011. 244 p.
Menezes Costa LdC, Maher CG, McAuley JH, Hancock MJ, Herbert RD, Refshauge KM, Henschke N. Prognosis for patients with chronic low back pain: inception cohort study. BMJ 2009;339:b3829.
Lannin NA, Cusick A, McCluskey A, Herbert RD. Effects of splinting on wrist contracture after stroke: A randomized controlled trial. Stroke 2007;38:111-116.
Hoang PD, Herbert RD, Todd G, Gorman RB, Gandevia SC. Passive mechanical properties of human gastrocnemius muscle-tendon unit, muscle fascicles and tendon in vivo. J Exp Biol 2007;210:4159-4168.
Pengel LHM, Refshauge KM, Maher CG, Nicholas M, Herbert RD, McNair P. Physiotherapist directed exercise, advice, or both for sub-acute low back pain: A randomized controlled trial. Ann Int Med 2007;146:787-796.
Carroll TJ, Herbert RD, Munn J, Lee M, Gandevia SC. Contralateral effects of unilateral strength training: evidence and possible mechanisms. J Appl Physiol 2006;101:1514-1522.
Herbert RD, Bø K. Analysis of quality of interventions in systematic reviews. BMJ 2005;33:507- 509.
Hoang PD, Gorman RB, Todd G, Gandevia SC, Herbert RD. A new method for measuring passive length-tension properties of human gastrocnemius muscle in vivo. J Biomech 2005;38:1333-1341.
Herbert RD, Moseley AM, Butler JE, Gandevia SC. Change in length of relaxed muscle fascicles and tendons with knee and ankle movement in humans. J Physiol 2002;539:637-645.
Pope RP, Herbert RD, Kirwan JD, Graham BJ. A randomized trial of pre-exercise stretching for prevention of lower-limb injury. Med Sci Sports Exerc 2000;32:271-277.

Associate Professor Janet TAYLOR
Taylor JL and McCloskey DI (1991) Illusions of head and visual target displacement induced by vibration of neck muscles. Brain 114: 755-759.
Ridding MC, Taylor JL & Rothwell JC (1995) The effect of voluntary contraction on cortico-cortical inhibition in human motor cortex. Journal of Physiology, 487: 541-548.
Taylor JL, Butler JE, Allen GM and Gandevia SC (1996) Changes in motor cortical excitability in human muscle fatigue. Journal of Physiology 490: 519-528.
Gandevia SC, Allen GM, Butler JE and Taylor JL (1996) Supraspinal factors in human muscle fatigue: evidence for suboptimal output from the motor cortex. Journal of Physiology 490: 529-536.
Taylor JL, Allen GM, Butler JE & Gandevia SC (2000) Supraspinal fatigue during intermittent maximal voluntary contractions of the human elbow flexors. Journal of Applied Physiology 89: 305-313.
Taylor JL, Todd G & Gandevia SC (2006) Evidence for a supraspinal contribution to human muscle fatigue. Clinical and Experimental Pharmacology and Physiology 33, 400-405.
Sogaard K, Gandevia SC, Todd G, Petersen NT & Taylor JL (2006) The effect of sustained low-intensity contractions on supraspinal fatigue in human elbow flexor muscle. Journal of Physiology 573, 511-523.
Taylor JL & Gandevia SC (2008) A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions. Journal of Applied Physiology 104, 542-550.
Taylor JL, Martin PG. (2009) Voluntary motor output is altered by spike-timing-dependent changes in the human corticospinal pathway. Journal of Neuroscience 29, 11708-11716.
McNeil CJ, Giesebrecht S, Gandevia SC, Taylor JL. (2011) Behaviour of the motoneurone pool in a fatiguing submaximal contraction. Journal of Physiology 589, 3533-3544.

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Caress the Detail: A Comprehensive MRI Atlas of the in Vivo Human Brain

This project aims to deliver the most comprehensive, detailed and stereotaxically accurate MRI atlas of the canonical human brain. In human neuroscience, researchers and clinicians almost always investigate images obtained from living individuals. Yet, there is no satisfactory MRI atlas of the human brain in vivo or post-mortem. There are some population-based atlases, which valiantly solve a number of problems, but they fail to address major needs. Most problematically, they segment only a small number of brain structures, typically about 50, and they are of limited value for the interpretation of a single subject/patient. In contrast to population-based approaches, the present project will investigate normal, living subjects in detail. We aim to define approximately 800 structures, as in the histological atlas of Mai, Majtanik and Paxinos (2016), and, thus, provide a “gold standard” for science and clinical practice. We will do this by obtaining high-resolution MRI at 3T and 7T of twelve subjects through a collaboration with Markus Barth from the Centre for Advanced Imaging at the University of Queensland (UQ). The limited number of subjects will allow us to image each for longer periods, obtaining higher resolution and contrast, and to invest the required time to produce unprecedented detail in segmentation. We will produce an electronic atlas for interpreting MR images, both as a tablet application and as an online web service. The tablet application will provide a convenient and powerful exegesis of brain anatomy for researchers and clinicians. The open access web service will additionally provide images, segmentation and anatomical templates to be used with most common MR-analysis packages (e.g., SPM, FSL, MINC, BrainVoyager). This will be hosted in collaboration with UQ, supporting and complementing their population-based atlas.