Research participant's arm in a machine designed for motor impairment study

Motor Impairment


Staff, students, visitors and colleagues

A number of staff at NeuRA are part of the core of the Program.
This includes:
Dr Annie BUTLER (
Dr Martin HÉROUX (
Dr Phu HOANG (
Dr Jasmine MENANT (

A number of doctoral and other students are part of the Program.
This includes:
James NUZZO (
Daniel SCHOENE (

We are also being joined by a number of key visitors, collaborators and other contributors.
This includes:
Bart BOLSTERLEE, PhD student from the Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Netherlands (to April 2014)
Joanna DIONG, Lecturer, University of Sydney (January 2014 on)
Andreas EJUPI, PhD student from Austrian University of Technology, Austria (January to May 2014)
Graham KERR, Professor, Queensland University of Technology, Brisbane, Australia (January 2014 on)
Yves GSCHWIND, post-doctoral researcher from University Hospital Basel and University of Basel, Switzerland (January to October 2014)
Hiske VAN DUINEN, post-doctoral researcher from the Karolinska Institute, Stockholm, Sweden (January to March 2014)
Leah BENT, Associate Professor at the University of Guelph, Canada (February to June 2014)

See what’s going on at NeuRA


Brain and Knee Muscle Weakness Study

Why Does Quadriceps Weakness Persist after Total Knee Replacement? An Exploration of Neurophysiological Mechanisms Total knee replacement is a commonly performed surgery for treating end-staged knee osteoarthritis. Although most people recover well after surgery, weakness of the quadriceps muscles (the front thigh muscles) persists long after the surgery (at least for 12 months), despite intensive physiotherapy and exercise. Quadriceps muscle weakness is known to be associated with more severe pain and greatly affect daily activities. This study aims to investigate the mechanisms underlying weakness of the quadriceps muscles in people with knee osteoarthritis and total knee replacement. We hope to better understand the relationship between the changes of the brain and a loss of quadriceps muscle strength after total knee replacement. The study might be a good fit for you if you: Scheduled to undergo a total knee replacement; The surgery is scheduled within the next 4 weeks; Do not have a previous knee joint replacement in the same knee; Do not have high tibial osteotomy; Do not have neurological disorders, epilepsy, psychiatric conditions, other chronic pain conditions; Do not have metal implants in the skull; Do not have a loss of sensation in the limbs. If you decide to take part you would: Be contacted by the researcher to determine your eligibility for the study Be scheduled for testing if you are eligible and willing to take part in the study Sign the Consent Form when you attend the first testing session Attend 3 testing sessions (approximately 2 hours per session): 1) before total knee replacement, 2) 3 months and 3) 6 months after total knee replacement. The testing will include several non-invasive measures of brain representations of the quadriceps muscles, central pain mechanisms, and motor function and questionnaires. Will I be paid to take part in the research study? You will be reimbursed ($50.00 per session) for travel and parking expenses associated with the research study visits. If you would like more information or are interested in being part of the study, please contact: Name: Dr Wei-Ju Chang Email: Phone: 02 9399 1260 This research is being funded by the Physiotherapy Research Foundation.