Alzheimer's disease

Dr Claire Shepherd, NeuRA Senior Research Officer & Sydney Brain bank Manager, assists with overseeing these projects

2011 Research Projects:

Inflammation and cell death mechanisms in Alzheimer’s disease - Inflammation is associated with the neuronal loss that underlies Alzheimer's disease. Our studies suggest that a protein called monocyte chemoattractant protein-1 (MCP-1) is an important mediator of this response. The aim of our research is to determine the association between MCP-1 and the underlying neuropathology and progression of Alzheimer's disease and to determine whether MCP-1 is a potential target for therapeutic intervention.

Academic Staff

Claire Shepherd, BScHons, PhD, Sydney Brain Bank Manager

Support Staff

Heidi Cartwright, BSc, P/T Senior Research Assistant
Amanda Gysbers, BBTEC with honours, Research Assistant
Francine Carew-Jones, BSc with honours, P/T Senior Research Assistant

Students

Primary supervisor Prof Glenda Halliday
Yue (Helen) Yang, MBBS, MSc, PhD Student – Neuronal senescence in Alzheimer’s and Parkinson’s diseases

Collaborators

David Small, Deputy Director, Menzies Research Institute, Hobart, Tasmania
James Vickers, Head, School of Medicine, Co-Director Wicking Dementia Research Centre, University of Tasmania
Elizabeth Coulson, Laboratory Head, Queensland Brain Institute
Brett Garner, ARC Future Fellow, University of Wollongong, Australia

Recent Publications:

Ma J-F, Huang Y, Chen S-D, Halliday GM (2010) The early macroautophagy marker Atg12 concentrates in neurons and endothelial in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 36:312-319.
Mitew S, Kirkcaldie MTK, Halliday GM, Shepherd CE, Vickers JC, Dickson TC (2010) Focal demyelination in Alzheimer’s disease and transgenic mouse models. Acta Neuropathol. 119:567-577.
Shepherd C, McCann H, Halliday G (2009) Variations in the neuropathology of familial Alzheimer’s disease. Acta Neuropathol. 118:37-52.
Sokolova A, Hill MD, Rahimi F, Warden LA, Halliday GM, Shepherd CE (2009) Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer’s disease. Brain Pathol. 19:392-398.
Woodhouse A, Shepherd CE, Sokolova A, Carroll VL, King AE, Halliday GM, Dickson TC, Vickers JC (2009) Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease. Acta Neuropathol. 117:19-29.

Key researchers 
glenda.halliday
claire.shepherd

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