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Genetic Repositories Australia (GRA)

FACILITY INFORMATION

In accordance with NHMRC Enabling Grant requirements GRA has established 3 committees:

  • Management Committee
  • Scientific Advisory Committee
  • Independent Appeals Committee

The Management Committee (MC) operates under defined terms of reference and provides management and oversight of the day-to-day management of the GRA facility. The MC role is to ensure that appropriate ethical standards are met, ensuring open access to all researchers, and overseeing the resolution of any disputes consistent with NHMRC Enabling Facility Access Policy.

  • The GRA MC comprises the four Chief Investigators and the Facility Manager.
  • Professor Peter Schofield BScAgr, PhD, DSc
  • Executive Director & CEO, Neuroscience Research Australia
  • Assoc Prof Juleen Cavanaugh BSc, MS, PhD
  • Senior Lecturer, Australian National University
  • Dr Susan Forrest BSc (Hons), D Phil, BA Business
  • Director, Australian Genome Research Facility Ltd
  • Professor John Hopper BA, MSc, PhD
  • NHMRC Senior Principal Research Fellow, The University of Melbourne
  • Steve Turner BAppSc, BSc (Hons), MSc, Grad Cert Man
  • Facility Manager, Genetic Repositories Australia.

A Scientific Advisory Committee (SAC) which consists of nine members. The SAC membership reflects a skills-based committee, with an appropriate mix of expertise to allow the SAC to provide advice in all areas of operations of the GRA facility. GRA’s SAC provides strategic advice and reviews progress towards establishing and operating GRA as an NHMRC Enabling Facility, including advice on governance, management and operations. The SAC is comprised of a majority of external appointments & includes all members from the GRA MC and the Facility Manager (Ex Officio).

External SAC members are listed below:

  • Professor Graham MacDonald, Formerly External Licensing Coordinator, Merck Sharp & Dohme (Australia)
  • Professor Don Chalmers, Faculty of Law, University of Tasmania
  • Theo Magoulas, Assistant University Solicitor, University of Technology Legal Services
  • Professor Phil Mitchell, Head School of Psychiatry, University of NSW
  • Dr Bruce Ross, Health Solutions Executive, Health Solutions Group Microsoft Australia.

An Independent Appeals Committee (IAC) of ’eminent persons’ who are independent of GRA and represent a range of consumer, scientific and social scientific disciplines. The IAC has been established to resolve any dispute concerning access to or operations of the facility and comprises individuals outside both Management and the SAC. The IAC comprises the following members:

  • Professor Ron Trent, Professor of Medicine at University of Sydney and Royal Prince Alfred Hospital
  • Peter Kemp, Founder of Kemp Strang Lawyers
  • A Consumer or Community Representative, (Position currently vacant)
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Caress the Detail: A Comprehensive MRI Atlas of the in Vivo Human Brain

This project aims to deliver the most comprehensive, detailed and stereotaxically accurate MRI atlas of the canonical human brain. In human neuroscience, researchers and clinicians almost always investigate images obtained from living individuals. Yet, there is no satisfactory MRI atlas of the human brain in vivo or post-mortem. There are some population-based atlases, which valiantly solve a number of problems, but they fail to address major needs. Most problematically, they segment only a small number of brain structures, typically about 50, and they are of limited value for the interpretation of a single subject/patient. In contrast to population-based approaches, the present project will investigate normal, living subjects in detail. We aim to define approximately 800 structures, as in the histological atlas of Mai, Majtanik and Paxinos (2016), and, thus, provide a “gold standard” for science and clinical practice. We will do this by obtaining high-resolution MRI at 3T and 7T of twelve subjects through a collaboration with Markus Barth from the Centre for Advanced Imaging at the University of Queensland (UQ). The limited number of subjects will allow us to image each for longer periods, obtaining higher resolution and contrast, and to invest the required time to produce unprecedented detail in segmentation. We will produce an electronic atlas for interpreting MR images, both as a tablet application and as an online web service. The tablet application will provide a convenient and powerful exegesis of brain anatomy for researchers and clinicians. The open access web service will additionally provide images, segmentation and anatomical templates to be used with most common MR-analysis packages (e.g., SPM, FSL, MINC, BrainVoyager). This will be hosted in collaboration with UQ, supporting and complementing their population-based atlas.
PROJECT