NeuRA Imaging

FACILITY INFORMATION

In July 2019, a new Philips Ingenia 3T Scanner has launched as a full time research instrument at NeuRA in the new Imaging Facility in the Margarete Ainsworth Building. Please access the new Imaging site via the button below.

NEW IMAGING SITE

The information below and any information available via the sub-site menu at the right of the page covers NeuRA’s older research-clinical shared scanner.

NeuRA has made a 3T MRI scanner available for research since 2003. This scanner is a Philips 3T TX MRI (upgraded May 2010).

The facility currently operates for research 50% of the time and is open for research to scientists on a merit-based, user pays basis. It supports an active MRI research community of researchers from UNSW, The University of Sydney, Macquarie University and The University of Western Sydney as well as researchers from interstate and international sites as required.

LATEST NEWS AND EVENTS

Workshop on Magnetic Resonance Spectroscopy

A two day course on magnetic resonance spectroscopy will be held at Neuroscience Research Australia, on Tuesday 28th and Wednesday 29th of November 2017.

Troubleshooting those MRI button boxes

A two day course on magnetic resonance spectroscopy will be held at Neuroscience Research Australia, on Tuesday 28th and Wednesday 29th of November 2017.

Collect your MRI data via Hippocampus

A two day course on magnetic resonance spectroscopy will be held at Neuroscience Research Australia, on Tuesday 28th and Wednesday 29th of November 2017.

New MRI simulator computer

A two day course on magnetic resonance spectroscopy will be held at Neuroscience Research Australia, on Tuesday 28th and Wednesday 29th of November 2017.

See what’s going on at NeuRA

FEEL THE BUZZ IN THE AIR? US TOO.

Cortical activity during balance tasks in ageing and clinical groups using functional near-infrared spectroscopy

Prof Stephen Lord, Dr Jasmine Menant Walking is not automatic and requires attention and brain processing to maintain balance and prevent falling over. Brain structure and function deteriorate with ageing and neurodegenerative disorders, in turn impacting both cognitive and motor functions.   This series of studies will investigate: How do age and/or disease- associated declines in cognitive functions affect balance control? How is this further impacted by psychological, physiological and medical factors (eg. fear, pain, medications)? How does the brain control these balance tasks?     Approach The experiments involve experimental paradigms that challenge cognitive functions of interest (eg.visuo-spatial working memory, inhibitory function). I use functional near-infrared spectroscopy to study activation in superficial cortical regions of interest (eg. prefrontal cortex, supplementary motor area…). The studies involve young and older people as well as clinical groups (eg.Parkinson’s disease).   Studies Cortical activity during stepping and gait adaptability tasks Effects of age, posture and task condition on cortical activity during reaction time tasks Influence of balance challenge and concern about falling on brain activity during walking Influence of lower limb pain/discomfort on brain activity during stepping   This research will greatly improve our understanding of the interactions between brain capacity, functions and balance control across ageing and diseases, psychological, physiological and medical factors, allows to identify targets for rehabilitation. It will also help identifying whether exercise-based interventions improve neural efficiency for enhanced balance control.
PROJECT

PUBLICATIONS

Characterizing Sexual Behavior in Frontotemporal Dementia.

Ahmed RM, Kaizik C, Irish M, Mioshi E, Dermody N, Kiernan MC, Piguet O, Hodges JR

We aimed to systematically quantify changes in sexual behavior, including current symptoms and changes from prior diagnoses, in behavioral-variant (bvFTD) and semantic dementia (SD), compared to Alzheimer's disease (AD). Overall loss of affection, reduced initiation of sexual activity, and responsiveness is an overwhelming feature of bvFTD. In contrast, aberrant or unusual sexual behavior is observed in the minority of bvFTD patients. The underlying pathophysiology of these changes likely reflects structural and functional changes in frontoinsular and limbic regions including the hypothalamus.

Eating behavior in frontotemporal dementia: Peripheral hormones vs hypothalamic pathology.

Ahmed RM, Latheef S, Bartley L, Irish M, Halliday GM, Kiernan MC, Hodges JR, Piguet O

To contrast the relationships of hormonal eating peptides and hypothalamic volumes to eating behavior and metabolic changes (body mass index [BMI]) in behavioral variant frontotemporal dementia (bvFTD) and semantic variant primary progressive aphasia (svPPA). Eating abnormalities are multifactorial in FTD. In bvFTD, they are in part related to hypothalamic degeneration, with potential disintegration of the network connections between the hypothalamus and orbitofrontal cortex/reward pathways. In svPPA, although hypothalamic volumes are preserved, this group experiences elevated AgRP levels similar to bvFTD, which predicts BMI in both groups. This finding highlights the potential key role of AgRP in eating and metabolic changes and provides a potential target for treatment to modify disease progression.

View all publications