NeuRA Imaging Centre


Identifying fMRI Model Violations with Lagrange Multiplier Tests (Ben Cassidy)

This software comprises tools for identifying model violation in Functional Magnetic Resonance Imaging analysis. The diagnostic tests are available as a MATLAB toolbox, and can be run from the MATLAB command line or incorporated in batch scripts as part of a full fMRI analysis pipeline.

The current version includes tests for violation of the following model assumptions:
– Double Gamma (canonical) hemodynamic response function
– Double Gamma and temporal derivative HRF (derivative as defined in SPM software)
– Double Gamma and temporal derivative HRF (derivative as defined in FSL software)
– Time-varying HRF
– Non-linear HRF

Download software (version 0.3)
Latest software version and development branches available at

Cassidy, B., Long, C.J., Rae, C and Solo, V.
Identifying fMRI model violations with Lagrange multiplier tests.
IEEE Transactions in Medical Imaging (in press 03/04/2012).

Cassidy, B and Solo, V.
fMRI Model Diagnostics for the Double Gamma and Temporal Derivative,
IEEE International Symposium on Biomedical Imaging, 2012

See what’s going on at NeuRA


Ten siblings. One third live (or have passed away) with dementia.

The scourge of dementia runs deep in Lorna Clement's family. Of the eleven children her dear parents raised, four live (or have passed away) with complications of the disease. Her mother also died of Alzheimer's disease, bringing the family total to five. This is the mystery of dementia - One family, with two very different ageing outcomes. You will have read that lifestyle is an important factor in reducing the risk of dementia. We also know diet is a key factor, and an aspect that Dr Ruth Peter's is exploring at NeuRA. Along with leading teams delivering high profile evidence synthesis work in the area of dementia risk reduction, Dr Peters has a particular interest in hypertension (that is, high blood pressure) and in the treatment of hypertension in older adults. “We have known for a while that treating high blood pressure reduces the risk of cardiovascular disease and stroke, but it is becoming clearer that controlling blood pressure may also help to reduce the risk of cognitive decline and dementia. Now we need to know what the best blood pressure is to protect brain health.” You are invited to read more about Lorna's story and Dr Peter's work, by clicking 'Read the full story' below. Please support dementia research at NeuRA Will you consider a gift today to help Dr Peter's unlock the secrets of healthy ageing and reduce the risk of dementia? Research into ageing and dementia at NeuRA will arm doctors and other medical professionals with the tools they need to help prevent dementia in our communities. Thank you for your support.