Dr Claire Shepherd in the Sydney Brain Bank labs

Sydney Brain Bank

FACILITY INFORMATION

RESEARCH OUTCOMES

The Sydney Brain Bank is committed to facilitating meaningful research into neurodegenerative conditions. The tissue generously donated to the Sydney Brain Bank has lead to many new discoveries by researchers not only here in the Sydney Brain Bank, but across Australia and around the world. These findings have been published in international peer reviewed scientific journals and also presented at national and international scientific meetings.
Recently the Sydney Brain Bank has published a perspective article that reviews the best practice for collection and storage of human brain material for diverse research purposes. You can read this article here.
For more details about this and other research activities, please see a list of the publications and presentations made possible by the tissue donated to the Sydney Brain Bank. To keep up to date with what we are doing in the Sydney Brain Bank, please follow us on Twitter.

 

Presentations and Publications arising from use of Sydney Brain Bank tissue

Sydney Brain Bank research outcomes

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Brain and Knee Muscle Weakness Study

Why Does Quadriceps Weakness Persist after Total Knee Replacement? An Exploration of Neurophysiological Mechanisms Total knee replacement is a commonly performed surgery for treating end-staged knee osteoarthritis. Although most people recover well after surgery, weakness of the quadriceps muscles (the front thigh muscles) persists long after the surgery (at least for 12 months), despite intensive physiotherapy and exercise. Quadriceps muscle weakness is known to be associated with more severe pain and greatly affect daily activities. This study aims to investigate the mechanisms underlying weakness of the quadriceps muscles in people with knee osteoarthritis and total knee replacement. We hope to better understand the relationship between the changes of the brain and a loss of quadriceps muscle strength after total knee replacement. The study might be a good fit for you if you: Scheduled to undergo a total knee replacement; The surgery is scheduled within the next 4 weeks; Do not have a previous knee joint replacement in the same knee; Do not have high tibial osteotomy; Do not have neurological disorders, epilepsy, psychiatric conditions, other chronic pain conditions; Do not have metal implants in the skull; Do not have a loss of sensation in the limbs. If you decide to take part you would: Be contacted by the researcher to determine your eligibility for the study Be scheduled for testing if you are eligible and willing to take part in the study Sign the Consent Form when you attend the first testing session Attend 3 testing sessions (approximately 2 hours per session): 1) before total knee replacement, 2) 3 months and 3) 6 months after total knee replacement. The testing will include several non-invasive measures of brain representations of the quadriceps muscles, central pain mechanisms, and motor function and questionnaires. Will I be paid to take part in the research study? You will be reimbursed ($50.00 per session) for travel and parking expenses associated with the research study visits. If you would like more information or are interested in being part of the study, please contact: Name: Dr Wei-Ju Chang Email: w.chang@neura.edu.au Phone: 02 9399 1260 This research is being funded by the Physiotherapy Research Foundation.  
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