Brain tissue arrives at the Sydney Brain Bank from around Australia and is processed and stored in different ways as a means of offering the greatest options for researchers who may want to utilise the tissues for their experiments.
Specifically, some of the tissue is frozen so that it can be used for DNA extraction or biochemical studies. This is done in the shortest time period possible to ensure viability of most neurochemicals, protein and RNA.
For participants with a strong family history of disease, the DNA may be screened for genes in which rare mutations have already been associated with neurodegeneration. The remaining tissue is fixed in formalin to preserve it for histological examination.
The Sydney Brain Bank at NeuRA aims to facilitate world class research and break throughs in ageing and neurodegenerative disorders. Globally it supplies tissue to 30-40 research projects a year, with many of these projects a collaborative effort between external research institutions. Lead by Dr Claire Shepherd, recently appointed to the position of Director of the Sydney Brain Bank, the team has developed a new method that […]