Brain tissue arrives at the Sydney Brain Bank from around Australia and is processed and stored in different ways as a means of offering the greatest options for researchers who may want to utilise the tissues for their experiments.
Specifically, some of the tissue is frozen so that it can be used for DNA extraction or biochemical studies. This is done in the shortest time period possible to ensure viability of most neurochemicals, protein and RNA.
For participants with a strong family history of disease, the DNA may be screened for genes in which rare mutations have already been associated with neurodegeneration. The remaining tissue is fixed in formalin to preserve it for histological examination.
NeuRA’s Dr Moyra Mortby presented at Uniting War Memorial Hospital’s free seminar on Healthy Brains this week. Dr Mortby shared her research into the neuropsychiatric symptoms of dementia. These are the challenging behaviours associated with dementia such as delusions, sleep disturbances, anxiety and agitation. “Neuropsychiatric symptoms are a diverse group of non-cognitive symptoms of dementia that are characterised by disturbed […]