Brain tissue arrives at the Sydney Brain Bank from around Australia and is processed and stored in different ways as a means of offering the greatest options for researchers who may want to utilise the tissues for their experiments.
Specifically, some of the tissue is frozen so that it can be used for DNA extraction or biochemical studies. This is done in the shortest time period possible to ensure viability of most neurochemicals, protein and RNA.
For participants with a strong family history of disease, the DNA may be screened for genes in which rare mutations have already been associated with neurodegeneration. The remaining tissue is fixed in formalin to preserve it for histological examination.
A new study by Prof Rob Herbert and his team is investigating muscle contracture in children with cerebral palsy. Contracture is a stiffening of muscles, even when the muscle is passive. It is not yet known whether contracture is a result of changes in the muscle, changes in the associated tendon, or a combination of both. Around 53 per cent […]