Brain tissue arrives at the Sydney Brain Bank from around Australia and is processed and stored in different ways as a means of offering the greatest options for researchers who may want to utilise the tissues for their experiments.
Specifically, some of the tissue is frozen so that it can be used for DNA extraction or biochemical studies. This is done in the shortest time period possible to ensure viability of most neurochemicals, protein and RNA.
For participants with a strong family history of disease, the DNA may be screened for genes in which rare mutations have already been associated with neurodegeneration. The remaining tissue is fixed in formalin to preserve it for histological examination.
By Prof Stephen Lord Falls are a major problem in the senior community with 1 in 3 people aged 65+ falling at least once a year and this risk increases as they age. This rate almost doubles for seniors living with Parkinson’s disease and cognitive impairment (60%), making falls the leading cause of injury-related disability and death in this age […]