Brain tissue arrives at the Sydney Brain Bank from around Australia and is processed and stored in different ways as a means of offering the greatest options for researchers who may want to utilise the tissues for their experiments.
Specifically, some of the tissue is frozen so that it can be used for DNA extraction or biochemical studies. This is done in the shortest time period possible to ensure viability of most neurochemicals, protein and RNA.
For participants with a strong family history of disease, the DNA may be screened for genes in which rare mutations have already been associated with neurodegeneration. The remaining tissue is fixed in formalin to preserve it for histological examination.
One in every 100 Australians lives with schizophrenia. No single cause of schizophrenia has been identified, and this has prevented the development of a cure. Current schizophrenia treatments are designed to suppress symptoms rather than target underlying causes of the disorder, only partially relieving these symptoms and can produce unwanted side effects. But now, in a breakthrough study from Professor […]