Brain tissue arrives at the Sydney Brain Bank from around Australia and is processed and stored in different ways as a means of offering the greatest options for researchers who may want to utilise the tissues for their experiments.
Specifically, some of the tissue is frozen so that it can be used for DNA extraction or biochemical studies. This is done in the shortest time period possible to ensure viability of most neurochemicals, protein and RNA.
For participants with a strong family history of disease, the DNA may be screened for genes in which rare mutations have already been associated with neurodegeneration. The remaining tissue is fixed in formalin to preserve it for histological examination.
In trying to understand the yet unknown causes about why older people fall over, we looked at fatigue. It is an ideal candidate. Firstly, fatigue is a common complaint for older people; more than 50 percent of people aged 70+ report fatigue in their daily activities. Secondly, fatigue affects sensory and movement functions that are associated with falling, such as […]