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Aidan Cashin is a Doctoral Candidate at Neuroscience Research Australia (NeuRA). A member of the pain research group headed by Dr James McAuley, his research deals with investigating the mechanisms of treatments for chronic low back pain. He is also interested in increasing the openness and transparency of research and is involved in developing a reporting guideline for studies that use mediation analysis.
Prior to commencing research, Aidan pursued a successful clinical career as an Accredited Exercise Physiologist, practicing primarily in the field of chronic musculoskeletal pain. Aidan also has a casual academic position at the University of New South Wales, within the School of Medical sciences and is involved in the teaching and evaluating of undergraduate exercise physiology students.
Complex Regional Pain Syndrome (CRPS) is a serious health condition, affecting approximately 20,000 people in Australia. It is characterised by severe burning, stinging and stabbing pain. People with CRPS are unable to use their painful limb and their ability to work or participate in normal social activities is severely restricted. Currently, there are no effective treatments for CRPS.
A vast body of research has demonstrated changes in brain processes in CRPS. The MEMOIR trial will investigate the effectiveness of two novel brain-directed treatments to reduce pain and improve function in people with CRPS.
MEMOIR consolidates the expertise of scientists and clinicians from NeuRA (A/Prof James McAuley, A/Prof Sylvia Gustin, Mr Michael Ferraro), the University of South Australia (Prof Lorimer Moseley), the University of Sydney (Prof Andrew McLachlan), the University of Notre Dame Australia Fremantle (Prof Benedict Wand, Prof Eric Visser), the University of Exeter (Prof Sallie Lamb), Brunel University London (Dr Neil O’Connell) and the University of Oxford (Dr Hopin Lee).
Due to the COVID-19 global pandemic, the commencement of MEMOIR has been delayed. Recruitment for MEMOIR will commence in September 2020.
If you are interested in being contacted about our CRPS research, please leave your details below and we will be in touch once recruitment begins.
Medicines are the most common treatment for back pain. The aim of this program of research is to improve our understanding of the clinical effects of medicines.
Studies currently in progress:
Medicines for Back Pain – Publications:
Medicines for Back Pain – Registrations of Study Protocols:
There are a growing number of studies using mediation analysis to understand the mechanisms of health interventions and exposures. Recent work has shown that the reporting of these studies is heterogenous and incomplete. This problem stifles clinical application, reproducibility, and evidence synthesis. The development and implementation of A Guideline for Reporting Mediation Analyses (AGReMA) will improve the standardization, transparency, and completeness in the reporting of studies that use mediation analysis to understand the mechanisms of health interventions and exposures.
Cashin AG, McAuley JH, Lamb SE, Hopewell S, Kamper SJ, Williams CM, Henschke N, Lee H. (2020). Development of A Guideline for Reporting Mediation Analyses (AGReMA). BMC Med Res Methodol 20(1):19. doi: 10.1186/s12874-020-0915-5. PMID: 32013883
THIAGO FOLLY Research Assistant
ANIKA HAIGH Research Assistant
PAULINE ZAHARA Research Assistant
DR IAN SKINNER Postdoctoral Research Fellow
DR MARKUS HUEBSCHER Postdoctoral Fellow
To develop and validate a prognostic model from a comprehensive range of candidate prognostic factors that can identify patients who are at risk of developing persistent pain following wrist or hand fracture. We developed and externally validated a prognostic model to predict persistent pain 4 months after a wrist or hand fracture. Future studies are needed to assess whether the accuracy of this model can be improved by updating and validating it in local settings.