Dr Alexander Burton


The effects of experimental muscle and skin pain on the static stretch sensitivity of human muscle spindles in relaxed leg muscles.

Birznieks I, Burton AR, Macefield VG

Effects of deep and superficial experimentally induced acute pain on muscle sympathetic nerve activity in human subjects.

Burton AR, Birznieks I, Bolton PS, Henderson LA, Macefield VG

Selective activation of muscle and skin nociceptors does not trigger exaggerated sympathetic responses in spinal-injured subjects.

Burton AR, Brown R, Macefield VG

To test whether selective noxious stimulation below lesion causes exaggerated sympathetic responses in human SCI. While hypertonic saline injected into muscle or skin induces strong pain, cutaneous vasoconstriction and sweat release in able-bodied subjects, we saw no evidence of exaggerated sympathoexcitation when these same noxious stimuli were delivered below lesion in subjects with SCI. This suggests that certain types of somatic noxious input may not trigger autonomic dysreflexia, and questions the concept that any painful stimuli originating below lesion can reliably trigger dysreflexia.

Effects of deep and superficial experimentally induced acute pain on skin sympathetic nerve activity in human subjects.

Burton AR, Birznieks I, Spaak J, Henderson LA, Macefield VG

Input-output relationships of a somatosympathetic reflex in human spinal injury.

Brown R, Burton A, Macefield VG

Spinal cord injury results in loss of supraspinal control of sympathetic outflow, yet preservation of spinal reflexes. Given the importance of reflex activation of sympathetic vasoconstrictor neurones to the generation of autonomic dysreflexia, we assessed the input-output relationship of the spinal somatosympathetic reflex induced by electrical activation of cutaneous afferents over the lower abdominal wall.

Autonomic hyper-vigilance in post-infective fatigue syndrome.

Kadota Y, Cooper G, Burton AR, Lemon J, Schall U, Lloyd A, Vollmer-Conna U

Reduced heart rate variability predicts poor sleep quality in a case-control study of chronic fatigue syndrome.

Burton AR, Rahman K, Kadota Y, Lloyd A, Vollmer-Conna U

Sleep-wake behavior in chronic fatigue syndrome.

Rahman K, Burton A, Galbraith S, Lloyd A, Vollmer-Conna U

Disturbances of the internal biological clock manifest as fatigue, poor concentration, and sleep disturbances-symptoms reminiscent of chronic fatigue syndrome (CFS) and suggestive of a role for circadian rhythm disturbance in CFS. We examined circadian patterns of activity, sleep, and cortisol secretion in patients with CFS. We found no evidence of circadian rhythm disturbance in CFS. However, the role of autonomic activity in the experience of unrefreshing sleep warrants further assessment. The activity symptom-relationship modelled here is of clinical significance in the approach to activity and symptom management in the treatment of CFS.

Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.

Beaumont A, Burton AR, Lemon J, Bennett BK, Lloyd A, Vollmer-Conna U

These findings reveal for the first time an association between reduced cardiac vagal tone and cognitive impairment in CFS and confirm previous reports of diminished vagal activity.

Somatosympathetic Vasoconstrictor Reflexes in Human Spinal Cord Injury: Responses to Innocuous and Noxious Sensory Stimulation below Lesion.

Macefield VG, Burton AR, Brown R

Reliability revisited: autonomic responses in the context of everyday well-being.

Patel V, Giesebrecht S, Burton AR, Cvejic E, Lemon J, Hadzi-Pavlovic D, Dain S, Lloyd A, Vollmer-Conna U

Viscerosympathetic reflexes in human spinal cord injury: relationships between detrusor pressure, blood pressure and skin blood flow during bladder distension.

Wallin BG, Burton AR, Elam M, Tamaddon K, Millard R, Macefield VG

Sympathetic Responses to Noxious Stimulation of Muscle and Skin.

Burton AR, Fazalbhoy A, Macefield VG

Autonomic dysreflexia: Somatosympathetic and viscerosympathetic vasoconstrictor responses to innocuous and noxious sensory stimulation below lesion in human spinal cord injury.

Brown R, Burton AR, Macefield VG

Microneurography from the posterior tibial nerve: a novel method of recording activity from the foot in freely standing humans.

Knellwolf TP, Burton AR, Hammam E, Macefield VG

Firing properties of muscle spindles supplying the intrinsic foot muscles of humans in unloaded and freestanding conditions.

Knellwolf TP, Burton AR, Hammam E, Macefield VG

Effects of tonic muscle pain on fusimotor control of human muscle spindles during isometric ankle dorsiflexion.

Smith LJ, Macefield VG, Birznieks I, Burton AR

The impact of childhood trauma on psychosocial functioning and physical health in a non-clinical community sample of young adults.

Beilharz JE, Paterson M, Fatt S, Wilson C, Burton A, Cvejic E, Lloyd A, Vollmer-Conna U

Given the fundamental emotional, social and physical development that occurs during the early years of life, childhood experiences are formative in shaping a person's life trajectory. Childhood trauma is a prevalent, multifaceted issue with well-documented long-term adverse health effects in clinical populations however; the impact of childhood trauma in the community is less clear. To address this, this study investigated how childhood trauma may impact physical and psychological health, sleep quality and autonomic function in a non-clinical community sample of adults. Together, these results highlight that childhood trauma can have lasting detrimental consequences on an individual's emotional and physical health, sleep quality and stress reactivity.