NHMRC Research Fellow, NeuRA
Senior Lecturer, UNSW
Affiliate, St Vincent’s Hospital Applied Medical Research Centre
+612 9399 1880
Dr Cysique’s cursus includes a PhD (09/2005, UNSW) in the neuropsychology of HIV infection, a 3-year post-doctoral fellowship at the prestigious HIV Neurobehavioral Research Centre (University of California San Diego, UCSD) where she was trained in the neuropsychology of HIV and Hep C. While at UCSD, Dr Cysique also received training in MRI of HIV and HCV at the Laboratory of Cognitive Imaging. Upon her return to Australia in 2008, she was awarded a three-year Brain Sciences UNSW fellowship, and subsequently a three-year NHMRC project grant and, several industries’ support grants. In 2009, Dr Cysique became a visiting research officer at Neuroscience Research Australia in the Brain Structure and Functions Theme where she received training in MR Spectroscopy and diffusion imaging. In 2013, Dr Cysique was awarded a four-year NHMRC Clinical Career Development Fellowship to pursue her independent research career into the chronic effects of HIV on brain functions. In June 2013, Dr Cysique was promoted to Senior Lecturer at UNSW Medicine. She is chief investigator on one multi-center international trial (Strategic Timing of AntiRetroviral Treatment- START), one multi-sites overseas study in Canada (Brain Health Now in HIV), and seven national studies/trials and leader of the HIV and Brain Ageing studies at NeuRA/UNSW. Dr Cysique has started to develop an angle of research into effects of alcohol on brain functions in teenagers in collaboration with Prof Caroline Rae, the study investigates the integrity of the white matter structure in teenagers who binge versus those who are alcohol abstainers. Dr Cysique’s research also investigates other conditions and factors that are relevant to the global HIV epidemic such as the development of cross-culturally valid tools and methods to assess cognitive function, mental health and the effects of alcohol on the brain.
This study is examining the neurobiological impact of binge alcohol consumption in 16-17 yo adolescents using magnetic resonance imaging and spectroscopy along with cognitive and behavioural measures.
Collaborators: Lucette Cysique, NeuRA; Maree Teesson, NDARC Louise Mewton NDARC
Lees, B., Mewton, L., Stapinski, L, Squeglia, L. M., Rae, C. & Teesson, M. (2018) Binge drinking in young people: Protocol for a systematic review of neuropsychological, neurophysiological and neuroimaging studies. BMJ Open 8 (7) e023629.
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There is a lack of evidence for the neurobiological underpinning of Asymptomatic Neurocognitive Impairment (ANI) and Mild Neurocognitive disorders (MND) in virally-suppressed HIV + persons. We hypothesized that such mild impairment would be associated with focal brain atrophy. ANI shows specific frontal WM atrophy to which HIV disease duration is a unique contributor. MND is characterised by more widespread subcortical atrophy.
To compare the effect of immediate versus deferred antiretroviral treatment (ART) on neuropsychological test performance in treatment-naive HIV-positive adults with more than 500 CD4 cells/μl. We observed substantial improvement in neurocognitive test performance during the first year in both study arms, underlining the importance of using a control group in studies assessing neurocognitive performance over time. Immediate ART neither benefitted nor harmed neurocognitive performance in individuals with CD4 cell counts above 500 cells/μl.