Dr Lucette Cysique

TEAM LEADER PROFILE

NHMRC Research Fellow, NeuRA Senior Lecturer, UNSW
Affiliate, St Vincent’s Hospital Applied Medical Research Centre

+612 9399 1880


Dr Cysique’s cursus includes a PhD (09/2005, UNSW) in the neuropsychology of HIV infection, a 3-year post-doctoral fellowship at the prestigious HIV Neurobehavioral Research Centre (University of California San Diego, UCSD) where she was trained in the neuropsychology of HIV and Hep C. While at UCSD, Dr Cysique also received training in MRI of HIV and HCV at the Laboratory of Cognitive Imaging. Upon her return to Australia in 2008, she was awarded a 3-year Brain Sciences UNSW fellowship, and subsequently a 3-year NHMRC project grant and, several industries’ support grants. In 2009, Dr Cysique became a visiting research officer at Neuroscience Research Australia in the Brain Structure and Functions Theme where she received training in Magnetic Resonance Spectroscopy and further training in MRI and DTI. In 2013, Dr Cysique was awarded a 4-year NHMRC Clinical Career Development Fellowship to pursue her independent research career into the chronic effects of HIV on brain functions. In June 2013, Dr Cysique was promoted to Senior Lecturer at UNSW Medicine. She is chief investigator on one multi-center international trial (Strategic Timing of AntiRetroviral Treatment- START), one multi-sites overseas study in Canada (Brain Health Now in HIV), and seven national studies/trials and leader of the HIV and Brain Ageing studies at NeuRA/UNSW. Dr Cysique has started to develop a research angle of research into effects of alcohol on brain functions in teenagers in collaboration with Prof Caroline Rae [LINk]. The study investigates the integrity of the white matter structure in teenagers who binge versus those who are alcohol abstainers.   

Projects Dr Lucette Cysique is currently involved with

CURRENT PROJECTS

Cross-culturally valid assessment of HIV-associated neurocognitive disorders

This project aims to develop a screening and standard neuropsychological battery that is cross-culturally valid for assessment of neurocognitive functions in HIV infection, in culturally and linguistically diverse Australians

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Cross-culturally valid assessment of HIV-associated neurocognitive disorders

Cross-disciplinary assessment of chronic HIV-associated neurocognitive disorder

This study focuses on HIV-associated neurocognitive disorder mechanisms in chronic and virally suppressed HIV infection as well as in patients who are aging and are at higer risks of cardiovascular diseases.

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Cross-disciplinary assessment of chronic HIV-associated neurocognitive disorder

CNS reservoirs in NeuroHIV

This project is dedicated to the identification and quantification of HIV reservoirs biomarkers in the Central Nervous System.

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CNS reservoirs in NeuroHIV

Strategic timing of antiretroviral treatment neurology sub-study

The aim of the Strategic Timing of AntiRetroviral Treatment (START) Neurology trial, is to investigate whether immediate initiation of antiretroviral treatment (ART) is superior to deferral of ART until the CD4+ declines below 350 cells/mm3 on neuropsychological functions.

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Strategic timing of antiretroviral treatment neurology sub-study

Brain health now for HIV-associated neurocognitive disorders

This study is focused on how to determine the prevalence and incidence of HIV-associated neurocognitive disorders in Canada and to assess cognitive rehabilitation/training strategies.

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Brain health now for HIV-associated neurocognitive disorders

Binge drinking and the adolescent brain

This study is examining effects of binge alcohol consumption in 16-17 year olds using questionnaires, magnetic resonance imaging and cognitive testing. It aims to determine whether binge consumption of alcohol is impacting adolescent brain and cognitive development.

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Binge drinking and the adolescent brain

RESEARCH TEAM

Kimberley Bassett

KIMBERLEY BASSETT

Michael Tobia

MICHAEL TOBIA

Vincent  Oxenham

DR VINCENT OXENHAM Visiting Research Officer

Chloe_Gott

CHLOE GOTT Masters student

JESSICA PATTI Research Assistant

PUBLICATIONS

Peripheral blood mononuclear cells HIV DNA levels impact intermittently on neurocognition.

Cysique LA, Hey-Cunningham WJ, Dermody N, Chan P, Brew BJ, Koelsch KK

To determine the contribution of peripheral blood mononuclear cells' (PBMCs) HIV DNA levels to HIV-associated dementia (HAD) and non-demented HIV-associated neurocognitive disorders (HAND) in chronically HIV-infected adults with long-term viral suppression on combined antiretroviral treatment (cART). PBMC HIV DNA plays a role in HAD pathogenesis, and this is moderated by pre-morbid cognitive ability in the context of long-term viral suppression. While the HIV DNA levels in PBMC are not associated with current non-demented HAND, increasing HIV DNA levels were associated with a decline in neurocognitive functions associated with HAND progression.

APOE ε4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals - a cross-sectional observational study.

Cysique LA, Hewitt T, Croitoru-Lamoury J, Taddei K, Martins RN, Chew CS, Davies NN, Price P, Brew BJ

Similarly to larger studies, APOE ε4 genotype was not directly associated with HAND, but moderated CSF levels of Aβ1-42 in a minority of participants. In the majority of participants, increased CSF p-tau levels were associated with current neurocognitive impairment. Combined CSF biomarker risk for AD in the current HIV+ sample is more than 10 times greater than in the Australian population of the same age. Larger prospective studies are warranted.

Advancing research in NeuroAIDS using collaboration and public data sharing.

Cysique LA

In this issue of BMC Medical Genomics Griffin et al. present a user-friendly and freely accessible HIV-associated neurocognitive disorder (HAND) genomic database that compiles viral (HIV-1) genetic sequences and other relevant clinical and treatment data. We discuss the benefits and caveats of public data sharing in NeuroAIDS research, while emphasizing the importance of such novel initiatives for advancing knowledge.

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