Dr Paulo Pelicioni

PUBLICATIONS

Head and trunk stability during gait before and after levodopa intake in Parkinson's disease subtypes.

Pelicioni PHS, Brodie MA, Latt MD, Menant JC, Menz HB, Fung VSC, Lord SR

People with the PD PIGD subtype exhibit impaired gait stability that is not improved and frequently worsened by levodopa. New non-pharmaceutical approaches, technological (e.g. cueing) or exercise-based (e.g. balance training) are required to improve or compensate for mediolateral gait instability in this subtype and ultimately prevent falls.

Executive functioning, concern about falling and quadriceps strength mediate the relationship between impaired gait adaptability and fall risk in older people.

Caetano MJD, Lord SR, Brodie MA, Schoene D, Pelicioni PHS, Sturnieks DL, Menant JC

Impaired gait adaptability is associated with high risk of falls in older adults. Reduced executive function, increased concern about falling and weaker quadriceps strength contribute significantly to this relationship. Training gait adaptability directly, as well as addressing the above mediators through cognitive, behavioural and physical training may maximise fall prevention efficacy.

Head and trunk stability during gait before and after levodopa intake in Parkinson's disease subtypes.

Pelicioni PHS, Brodie MA, Latt MD, Menant JC, Menz HB, Fung VSC, Lord SR

People with the PD PIGD subtype exhibit impaired gait stability that is not improved and frequently worsened by levodopa. New non-pharmaceutical approaches, technological (e.g. cueing) or exercise-based (e.g. balance training) are required to improve or compensate for mediolateral gait instability in this subtype and ultimately prevent falls.

Executive functioning, concern about falling and quadriceps strength mediate the relationship between impaired gait adaptability and fall risk in older people.

Caetano MJD, Lord SR, Brodie MA, Schoene D, Pelicioni PHS, Sturnieks DL, Menant JC

Impaired gait adaptability is associated with high risk of falls in older adults. Reduced executive function, increased concern about falling and weaker quadriceps strength contribute significantly to this relationship. Training gait adaptability directly, as well as addressing the above mediators through cognitive, behavioural and physical training may maximise fall prevention efficacy.

RCVibro System: full description of a custom-made vibratory system and its reliability.

Pereira MP, Pelicioni PHS, Gobbi LTB

To describe technical details of a custom-made vibratory system (RCVibro System), as well as to determine its reliability and functionality. We conclude that RCVibro System is a highly reliable system. The results demonstrate the potential usage of RCVibro System in clinical and research settings. Further investigation is needed in people with motor and neurological disorders.

Sensorimotor and Cognitive Predictors of Impaired Gait Adaptability in Older People.

Caetano MJ, Menant JC, Schoene D, Pelicioni PH, Sturnieks DL, Lord SR

Superior executive function, fast processing speed, and good muscle strength and balance were all associated with successful gait adaptability. Processing speed appears particularly important for precise foot placements; cognitive capacity for step length adjustments; and early and/or additional cognitive processing involving the inhibition of a stepping pattern for obstacle avoidance. This information may facilitate fall risk assessments and fall prevention strategies.

Age-related changes in gait adaptability in response to unpredictable obstacles and stepping targets.

Caetano MJ, Lord SR, Schoene D, Pelicioni PH, Sturnieks DL, Menant JC

To evaluate age-related changes in gait adaptability in response to obstacles or stepping targets presented at short notice, i.e.: approximately two steps ahead. Compared with their younger counterparts, the older adults exhibited a more conservative adaptation strategy characterised by slow, short and multiple steps with longer time in double support. Even so, they demonstrated poorer stepping accuracy and made more stepping errors. This reduced gait adaptability may place older adults at increased risk of falling when negotiating unexpected hazards.

Manipulating vibratory devices' orientation and position enhances proprioceptive disturbance during upright stance.

Pereira MP, Pelicioni PH, Gobbi LT

We tested local vibration effects during upright standing considering: (i) the orientation of vibratory devices in relation to muscle fibres; (ii) the muscle region stimulated; and (iii) the number of stimulation spots. Results showed a higher balance disturbance with vibration devices oriented parallel to triceps surae muscle fibres. The single stimulation of the proximal region of the tibialis anterior muscle belly induces the same proprioceptive disturbance as stimulating multiple regions simultaneously.

PARKINSON'S DISEASE PATIENTS WITH DOMINANT HEMIBODY AFFECTED BY THE DISEASE RELY MORE ON VISION TO MAINTAIN UPRIGHT POSTURAL CONTROL.

Lahr J, Pereira MP, Pelicioni PH, De Morais LC, Gobbi LT

This study assesses the association between disease onset side (dominant or non-dominant) and vision on postural control of Parkinson's disease patients. Patient volunteers composed two groups, according to the onset side affected: Dominant group (n=9; M age=66.1 yr., SD=7.2; 6 women, 3 men) and Non-dominant group (n=9; M age=67.4 yr., SD=6.4; 6 women, 3 men). The groups' postural control was assessed by posturography during quiet upright stance in two conditions, Eyes open and Eyes closed. Two-way analyses of variance (ANOVAs; group×condition) with repeated measures for the second factor assessed the differences associated with affected hemibody and vision on postural control. Analyses indicated that patients with the dominant side affected also presented significantly greater variation in center of pressure than those with the non-dominant side affected, mainly in the Eyes closed condition. The results demonstrate a higher reliance on vision in the dominant side, possibly to compensate somatosensory system impairments. These results also highlight the importance of analyzing the hemibody affected by the disease when postural control is assessed in this population.

Does proprioceptive system stimulation improve sit-to-walk performance in healthy young adults?

Pereira MP, Pelicioni PH, Lahr J, Gobbi LT
[Purpose] Sit-to-walk performance is linked to proper proprioceptive information processing. Therefore, it is believed that an increase of proprioceptive inflow (using muscle vibration) might improve sit-to-walk performance. However, before testing muscle vibration effects on a frail population, assessment of its effects on healthy young people is necessary. Thus, the aim of this study was to investigate the effects of muscle vibration on sit-to-walk performance in healthy young adults. [Subjects and Methods] Fifteen young adults performed the sit-to-walk task under three conditions: without vibration, with vibration applied before movement onset, and with vibration applied during the movement. Vibration was applied bilaterally for 30 s to the tibialis anterior, rectus femoris, and upper trapezius muscles bellies. The vibration parameters were as follows: 120 Hz and 1.2 mm. Kinematics and kinetic data were assessed using a 3D motion capture system and two force plates. The coordinates of reflective markers were used to define the center-of-mass velocities and displacements. In addition, the first step spatiotemporal variables were assessed. [Results] No vibration effect was observed on any dependent variables. [Conclusion] The results show that stimulation of the proprioceptive system with local muscle vibration does not improve sit-to-walk performance in healthy young adults.

Effect of different types of exercises on psychological and cognitive features in people with Parkinson's disease: a randomized controlled trial.

Gobbi LTB, Pelicioni PHS, Lahr J, Lirani-Silva E, Teixeira-Arroyo C, Santos PCRD

We aimed to compare the effect of different exercise modalities (functional mobility, multimodal and cognitive) and length (4 and 8 months) on psychological and cognition in people with PD. This study followed the CONSORT extension for non-pharmacological trials. An intervention that requires high complexity and specific activities, such as locomotor and cognitive exercise, provides a maintenance effect against the degeneration in cognition associated with the progression of PD and thus can delay the progressive decline in cognitive function in PD.

COVID-19 will severely impact older people's lives, and in many more ways than you think!

Pelicioni PHS, Lord SR

Biomechanical analysis of sit-to-walk in different Parkinson's disease subtypes.

Pelicioni PHS, Pereira MP, Lahr J, Rodrigues MML, Gobbi LTB

Motor adjustments during time-constrained sit-to-walk in people with Parkinson's disease.

Pelicioni PHS, Pereira MP, Lahr J, Rodrigues MML, de Morais LC, Moraes R, Gobbi LTB

We observed that people with PD exhibited more restrictions when compared with healthy older adults on their STW performance, COM and GRF parameters during the STW under time constraint. Some clinical impairments usually observed in people with PD might explain their STW performance such as, motor planning deficits, less automatic motor control and mediolateral balance impairments.

Falls in Parkinson's Disease Subtypes: Risk Factors, Locations and Circumstances.

Pelicioni PHS, Menant JC, Latt MD, Lord SR

Prefrontal cortical activation measured by fNIRS during walking: effects of age, disease and secondary task.

Pelicioni PHS, Tijsma M, Lord SR, Menant J

Increased PFC activation was most common in studies that involved walks comprising secondary verbal fluency and arithmetic tasks. Clinical groups generally showed increased PFC activation irrespective of type of secondary task performed during walking which suggests these groups require more attentional resources for safe walking. Systematic review registration number: PROSPERO 2017 – CRD42017059501.

Head and trunk stability during gait before and after levodopa intake in Parkinson's disease subtypes.

Pelicioni PHS, Brodie MA, Latt MD, Menant JC, Menz HB, Fung VSC, Lord SR

People with the PD PIGD subtype exhibit impaired gait stability that is not improved and frequently worsened by levodopa. New non-pharmaceutical approaches, technological (e.g. cueing) or exercise-based (e.g. balance training) are required to improve or compensate for mediolateral gait instability in this subtype and ultimately prevent falls.

Executive functioning, concern about falling and quadriceps strength mediate the relationship between impaired gait adaptability and fall risk in older people.

Caetano MJD, Lord SR, Brodie MA, Schoene D, Pelicioni PHS, Sturnieks DL, Menant JC

Impaired gait adaptability is associated with high risk of falls in older adults. Reduced executive function, increased concern about falling and weaker quadriceps strength contribute significantly to this relationship. Training gait adaptability directly, as well as addressing the above mediators through cognitive, behavioural and physical training may maximise fall prevention efficacy.

Sensorimotor and Cognitive Predictors of Impaired Gait Adaptability in Older People.

Caetano MJD, Menant JC, Schoene D, Pelicioni PHS, Sturnieks DL, Lord SR

Superior executive function, fast processing speed, and good muscle strength and balance were all associated with successful gait adaptability. Processing speed appears particularly important for precise foot placements; cognitive capacity for step length adjustments; and early and/or additional cognitive processing involving the inhibition of a stepping pattern for obstacle avoidance. This information may facilitate fall risk assessments and fall prevention strategies.

RCVibro System: full description of a custom-made vibratory system and its reliability.

Pereira MP, Pelicioni PHS, Gobbi LTB

To describe technical details of a custom-made vibratory system (RCVibro System), as well as to determine its reliability and functionality. We conclude that RCVibro System is a highly reliable system. The results demonstrate the potential usage of RCVibro System in clinical and research settings. Further investigation is needed in people with motor and neurological disorders.

Age-related changes in gait adaptability in response to unpredictable obstacles and stepping targets.

Caetano MJ, Lord SR, Schoene D, Pelicioni PH, Sturnieks DL, Menant JC

To evaluate age-related changes in gait adaptability in response to obstacles or stepping targets presented at short notice, i.e.: approximately two steps ahead. Compared with their younger counterparts, the older adults exhibited a more conservative adaptation strategy characterised by slow, short and multiple steps with longer time in double support. Even so, they demonstrated poorer stepping accuracy and made more stepping errors. This reduced gait adaptability may place older adults at increased risk of falling when negotiating unexpected hazards.

Manipulating vibratory devices' orientation and position enhances proprioceptive disturbance during upright stance.

Pereira MP, Pelicioni PH, Gobbi LT

Does proprioceptive system stimulation improve sit-to-walk performance in healthy young adults?

Pereira MP, Pelicioni PH, Lahr J, Gobbi LT