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Professor Peter Schofield AO

PUBLICATIONS

Specific and common genes implicated across major mental disorders: a review of meta-analysis studies.

Gatt JM, Burton KL, Williams LM, Schofield PR

Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood.

Gatt JM, Williams LM, Schofield PR, Dobson-Stone C, Paul RH, Grieve SM, Clark CR, Gordon E, Nemeroff CB

These findings suggest that the HTR3A CC genotype may be associated with alterations in brain structures central to emotion processing, particularly when exposed to stress, and further highlight the potential role of the serotonin system in the pathophysiology of affective disorders. In contrast, those individuals with the T allele, in particular the TT genotype, may be more protected from such alterations combined with minimal exposure to ELS events.

COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias.

Williams LM, Gatt JM, Grieve SM, Dobson-Stone C, Paul RH, Gordon E, Schofield PR

'Negativity bias' in risk for depression and anxiety: brain-body fear circuitry correlates, 5-HTT-LPR and early life stress.

Williams LM, Gatt JM, Schofield PR, Olivieri G, Peduto A, Gordon E

Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: evidence from cognition, the P300 and fronto-hippocampal systems.

Schofield PR, Williams LM, Paul RH, Gatt JM, Brown K, Luty A, Cooper N, Grieve S, Dobson-Stone C, Morris C, Kuan SA, Gordon E

Brain derived neurotrophic factor Val66Met polymorphism, the five factor model of personality and hippocampal volume: Implications for depressive illness.

Joffe RT, Gatt JM, Kemp AH, Grieve S, Dobson-Stone C, Kuan SA, Schofield PR, Gordon E, Williams LM

Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety.

Gatt JM, Nemeroff CB, Dobson-Stone C, Paul RH, Bryant RA, Schofield PR, Gordon E, Kemp AH, Williams LM

A polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial index.

Williams LM, Gatt JM, Kuan SA, Dobson-Stone C, Palmer DM, Paul RH, Song L, Costa PT, Schofield PR, Gordon E

10-05 Genotypes and neural binding in negative affect: the contribution of genetic polymorphisms to 40 Hz gamma phase synchrony.

Gatt JM, Kuan S, Dobson-Stone C, Paul RH, Schofield PR, Gordon E, Williams LM

A genotype-endophenotype-phenotype path model of depressed mood: integrating cognitive and emotional markers.

Gatt JM, Clark CR, Kemp AH, Liddell BJ, Dobson-Stone C, Kuan SA, Schofield PR, Williams LM

Investigation of MCPH1 G37995C and ASPM A44871G polymorphisms and brain size in a healthy cohort.

Dobson-Stone C, Gatt JM, Kuan SA, Grieve SM, Gordon E, Williams LM, Schofield PR

10-01 Understanding genotype-phenotype relationships using the Brain Resource International Database: Implications for psychiatric conditions.

Dobson-Stone C, Gatt JM, Kuan S, Paul RH, Gordon E, Williams LM, Schofield PR

10-03 Identifying pathways to depressed mood and cognitive dysfunction: the BDNF Val66Met polymorphism and early life stress.

Gatt JM, Kuan S, Dobson-Stone C, Paul RH, Schofield PR, Gordon E, Williams LM

10-02 The neurodevelopmental effects of apolipoprotein E alleles on brain function.

Alexander DM, Gatt JM, Kuan S, Dobson-Stone C, Todd EG, Schofield PR, Gordon E, Williams LM

10-05 Genotypes and neural binding in negative affect: the contribution of genetic polymorphisms to 40 Hz gamma phase synchrony.

Gatt JM, Kuan S, Dobson-Stone C, Paul RH, Schofield PR, Gordon E, Williams LM

A negative association between brainstem pontine grey-matter volume, well-being and resilience in healthy twins.

Gatt JM, Burton KLO, Routledge KM, Grasby KL, Korgaonkar MS, Grieve SM, Schofield PR, Harris AWF, Clark CR, Williams LM

Associations with altered grey matter of the pontine nuclei suggest that basic sensory processes, such as arousal, startle, memory consolidation and/or emotional conditioning, may have a role in well-being and resilience.

Using Longitudinal Survey Data to Estimate Mental Health Related Transitions to a Disability Pension: Analysis of an Australian Household Panel Study.

Schofield TP, Kiely KM, Mykletun A, Harvey SB, Butterworth P

This study examined the association between mental ill-health and subsequent receipt of a disability pension in Australia, and assessed how the strength of the association varied in relation to the duration between mental health measurement and reported disability pension receipt. Mental ill-health is an independent risk factor for disability pension receipt, and proximal circumstances better capture this association than mental health measured earlier.