Postdoctoral Research Fellow
Dr Saurab Sharma is a postdoctoral research fellow at NeuRA. His postdoctoral fellowship is partly supported by International Association for the Study of Pain (IASP) John J. Bonica Fellowship. His PhD focused on improving pain research, assessment, and management in Nepal which was rated as a thesis of exceptional quality (2020). Prior to commencing his PhD in 2017, Saurab worked as a musculoskeletal physiotherapist and lecturer in Nepal for a decade. During this time, he successfully supervised nine Bachelor of Physiotherapy honour’s theses at Kathmandu University.
His current research includes developing global strategies for improving musculoskeletal health and developing and testing assessment methods and interventions for pain. He is specifically interested in musculoskeletal pain (e.g., back pain, osteoarthritis), other chronic pain conditions (e.g., complex regional pain syndrome), and cross-cultural pain management. He is also interested in improving evidence-based practice, patient-centred care, and shared decision making in healthcare. He has published over 30 peer-reviewed papers. Follow Saurab’s work on Google Scholar.
He is currently an associate editor for BMC Musculoskeletal Disorders. He frequently reviews papers for several prestigious pain, physiotherapy, and rehabilitation journals; and international conferences such as the World Physiotherapy Congress and the World Pain Congress.
He is one of the Commissioners for the Lancet Commission on Osteoarthritis. He is also a founding member of Global Alliance for Pain Patient Advocates (GAPPA) of the IASP and an active member of Pain, Mind, and Movement special interest group of the IASP.
|What is Complex Regional Pain Syndrome (CRPS)?
CRPS is a disabling pain disorder. It affects approximately 5,000 people in Australia annually. CRPS is characterised by severe burning, stinging and stabbing pain. People with CRPS may not be able to use their affected limb and their ability to work or participate in normal social activities can be severely restricted. Currently, there are no interventions for CRPS whose efficacy is supported by high-quality evidence.
What is the MEMOIR Trial?
The MEMOIR trial is a Commonwealth Government-funded, randomised controlled trial testing two novel treatments for CRPS. MEMOIR will test whether a drug, memantine, and a rehabilitation program, Graded Motor Imagery, produce greater improvements in pain intensity and pain interference than placebo and standard care for CRPS.
The MEMOIR trial will be delivered remotely, via Telehealth, allowing Australia-wide recruitment of 160 participants. Eligible participants will be randomly allocated to one of the four treatment groups:
What is Memantine?
Memantine is currently approved in Australia for the treatment of moderately severe Alzheimer’s disease, but not for CRPS. Preliminary evidence suggests that memantine may be effective in reducing pain intensity in people with CRPS.
What is Graded Motor Imagery?
Graded Motor Imagery is a graded rehabilitation program that uses a combination of brain-directed movement activities and patient education. The Graded Motor Imagery activities include laterality tasks, imagined movements, mirror therapy and functional rehabilitation tasks. Preliminary evidence suggests that Graded Motor Imagery may be effective in reducing pain intensity and improving function in people with CRPS. The Graded Motor Imagery treatment protocol has been recently updated to be delivered in the MEMOIR trial.
What is usual care?
Usual care is the continuation of your current management for CRPS, excluding the therapies outlined in the exclusion criteria. This might include medical, physical or psychological management of CRPS.
|Will these treatments improve my CRPS?
The effectiveness of these treatments is not known. We are attempting to find this out by conducting this research study. MEMOIR is the first, large, high-quality clinical trial to evaluate of the effects of memantine and Graded Motor Imagery for CRPS.
What is required as a MEMOIR participant?
Participation in this trial requires a large time commitment for participants. The time commitment varies depending on the group that you are allocated to. Study participants will be asked to:
The trial treatment period will run for a period of 16 weeks. After this, we will require you to complete two further assessments at 6 months and 12 months.
Will I get paid to be a participant?
Participation in this study will not cost you anything, nor will you be paid.
What is MEMOIR’s eligibility criteria?
To be eligible for the MEMOIR trial, you must:
You will not be eligible to participate in the MEMOIR trial if:
How can I contact the MEMOIR study team?
02 9399 1627
MEMOIR Research Team
MEMOIR consolidates the expertise of the following international scientists and clinicians:
The MEMOIR trial has been approved by the Ethics Review Committee (RPAH Zone) of the Sydney Local Health District, protocol number: X20-0325.
THIAGO FOLLY Research Assistant
ANIKA HAIGH Research Assistant
PAULINE ZAHARA Research Assistant
DR IAN SKINNER Postdoctoral Research Fellow