Ying Xu


Who is driving and who is prone to have traffic accidents? A systematic review and meta-analysis among people with seizures.

Xu Y, Zhou Z, Shanthosh J, Hackett ML, Anderson CS, Glozier N, Somerville E

Prevalence of Driving and Traffic Accidents among People with Seizures: A Systematic Review.

Xu Y, Shanthosh J, Zhou Z, Somerville E, Anderson CS, Glozier N, Hackett ML

Epilepsy influences the ability to drive. We undertook a systematic review to determine the prevalence of driving or holding a driver's license among people with seizures, the prevalence of traffic accidents among those who drive, and factors that may explain heterogeneity in these point estimates. There is considerable variation in the prevalence of driving after a diagnosis of epilepsy and in reported motor vehicle accidents. Further efforts are required to better understand the impact of epilepsy, and epilepsy surgery, on driving and road safety, especially where driving continues in violation of restrictions. Policy changes are needed to encourage the introduction of available and affordable alternatives for driving, for example, developing public transport networks, and promoting subsidy schemes to encourage use of public transport, taxis, Uber, and Lyft, among people experiencing seizures.

Disability patterns over the first year after a diagnosis of epilepsy.

Xu Y, Neuen DR, Glozier N, Nikpour A, Somerville E, Bleasel A, Ireland C, Anderson CS, Hackett ML

To determine the patterns and predictors of disability over the first 12 months after a diagnosis of epilepsy. Most people report problems with emotional health after a diagnosis of epilepsy but many recover over the next 12 months. Services addressing the social and psychological impact of diagnosis may be needed to improve outcome.

Return to driving after a diagnosis of epilepsy: A prospective registry study.

Xu Y, Hackett ML, Glozier N, Nikpour A, Somerville E, Bleasel A, Ireland C, Anderson CS

To determine the frequency and predictors of return to driving within 1 year after a diagnosis of epilepsy.

Frequency, determinants, and effects of early seizures after thrombolysis for acute ischemic stroke: The ENCHANTED trial.

Xu Y, Hackett ML, Chalmers J, Lindley RI, Wang X, Li Q, Robinson T, Arima H, Lavados PM, Anderson CS,

In thrombolysis-treated patients with acute ischemic stroke, seizures are uncommon, occur early, and predict poor recovery.

Frequency and predictors of psychological distress after a diagnosis of epilepsy: A community-based study.

Xu Y, Hackett ML, Glozier N, Nikpour A, Bleasel A, Somerville E, Lawson J, Jan S, Hyde L, Todd L, Martiniuk A, Ireland C, Anderson CS

The objective of the study was to determine the frequency and predictors of psychological distress after a diagnosis of epilepsy. Psychological distress is common and fluctuates in frequency after a diagnosis of epilepsy. Those with premorbid psychological, psychosocial, and family problems are at high risk of this adverse outcome.

Frequency of a false positive diagnosis of epilepsy: A systematic review of observational studies.

Xu Y, Nguyen D, Mohamed A, Carcel C, Li Q, Kutlubaev MA, Anderson CS, Hackett ML

False positive diagnosis of epilepsy is common, even though there is considerable heterogeneity across studies. All potential imitators should be considered and clinicians should be cautious introducing AEDs without a definite diagnosis given the risk of side effects, and the possible impact on legal driving status and employment.

Effects of Low-Dose and Very Low-Dose Ketamine among Patients with Major Depression: a Systematic Review and Meta-Analysis.

Xu Y, Hackett M, Carter G, Loo C, Gálvez V, Glozier N, Glue P, Lapidus K, McGirr A, Somogyi AA, Mitchell PB, Rodgers A

Low-dose ketamine appears more effective than very low dose. There is substantial heterogeneity in clinical response, with remission among one-fifth of patients at 1 week but most others having benefits that are less durable. Larger, longer term parallel group trials are needed to determine if efficacy can be extended and to further assess safety.

Benign paroxysmal positional vertigo in Meniere's disease: systematic review and meta-analysis of frequency and clinical characteristics.

Kutlubaev MA, Xu Y, Hornibrook J

Effects of continuous positive airway pressure on depression and anxiety symptoms in patients with obstructive sleep apnoea: results from the sleep apnoea cardiovascular Endpoint randomised trial and meta-analysis.

Zheng D, Xu Y, You S, Hackett ML, Woodman RJ, Li Q, Woodward M, Loffler KA, Rodgers A, Drager LF, Lorenzi-Filho G, Wang X, Quan WW, Tripathi M, Mediano O, Ou Q, Chen R, Liu Z, Zhang X, Luo Y, McArdle N, Mukherjee S, McEvoy RD, Anderson CS

Dual diagnosis of epilepsy and psychogenic nonepileptic seizures: Systematic review and meta-analysis of frequency, correlates, and outcomes.

Kutlubaev MA, Xu Y, Hackett ML, Stone J

Comparison of Treatment Rates of Depression After Stroke Versus Myocardial Infarction: A Systematic Review and Meta-Analysis of Observational Data.

Ladwig S, Zhou Z, Xu Y, Wang X, Chow CK, Werheid K, Hackett ML

Depression after stroke and myocardial infarction (MI) is common but often assumed to be undertreated without reliable evidence being available. Thus, we aimed to determine treatment rates and investigate the application of guidelines in these conditions. Despite the high frequency of depression after stroke and MI and the existence of efficacious treatment strategies, people often remain untreated. Innovative strategies are needed to increase the use of effective antidepressive interventions in patients with cardiovascular disease.

Is Regular Screening for Intracranial Aneurysm Necessary in Patients with Autosomal Dominant Polycystic Kidney Disease? A Systematic Review and Meta-analysis.

Zhou Z, Xu Y, Delcourt C, Shan J, Li Q, Xu J, Hackett ML

Screening for intracranial aneurysm is recommended in patients with ADPKD when there is a family history of haemorrhagic stroke or intracranial aneurysm and when they are from China, Japan or Europe (Germany, Poland). Based on existing data, regular imaging follow-up is not supported. High-quality, prospective studies are needed in the future.

RNA interference of GADD153 protects photoreceptors from endoplasmic reticulum stress-mediated apoptosis after retinal detachment.

Zhu H, Qian J, Wang W, Yan Q, Xu Y, Jiang Y, Zhang L, Lu F, Hu W, Zhang X, Wang F, Sun X

ER stress-mediated pathway is involved in photoreceptor cell apoptosis after RD. GADD153 is a key regulatory molecule regulating ER-stress pathways and plays a crucial role in the apoptosis of photoreceptor cells after RD.

Response to letter to editor regarding: EB_2017_222_R1 frequency and predictors of psychological distress after a diagnosis of epilepsy: A community-based study: Methodological issues.

Xu Y, Li Q, Anderson CS