What is the Sydney Brain Bank?
The Sydney Brain Bank (SBB) is a biobanking facility that collects, characterises, stores and distributes human brain and spinal cord tissue for research into disorders of the brain and mind.
The facility was established in 2009 and is located at NeuRA, one of Australia’s leading institutes in brain research.
The Sydney Brain Bank houses specialised laboratories and equipment designed for handling, dissecting and staining human brain and spinal cord tissue specimens. Our staff are highly trained in neuroanatomy, histology and immunohistochemistry and also have extensive skills in neuropathology and microscopy (brightfield, fluorescence and confocal).
We are accredited through the NSW Health Biobanking certification program and operate within a national network of brain banks to facilitate requests for tissue and to build strong cohorts for research. We also partner with international consortia investigating the genetic architecture of brain and mind disorders and improved neuropathological characterisation.
How does the brain bank work?
The Sydney Brain Bank currently works with 10 brain donor programs. These focus on conditions such as Alzheimer’s disease, Parkinson’s disease, motor neuron disease, Huntington’s disease, frontotemporal lobar degeneration and neurologically unaffected individuals.
In 2020, the National Rugby League (NRL) announced its support of the most recent donor program to the Sydney Brain Bank. This research at NeuRA is looking into the prevalence of chronic traumatic encephalopathy (CTE) and impact of sports-related brain injuries.
Our brain donors undergo detailed health assessments during life in order to examine how neurodegenerative changes may or may not be impacting on their quality of life.
After death, brain and spinal cord tissue collection is carried out in a NSW Hospital mortuary according to standardised autopsy procedures. All tissue is comprehensively characterised according to standardised research diagnostic criteria before it is banked for use. Researchers are invited to submit proposals for studies utilising these tissues, which are reviewed with the help of an independent scientific review committee. For more information about accessing tissue please head to our tissue request page – https://sbb.neura.edu.au/about
Why is this research so important?
Human brain tissue studies are vital to our understanding of neurodegenerative disorders, mental illness and normal ageing and have led to the development of diagnostic tools, the discovery of new disorders, novel genes and disease subtypes, the elucidation of disease mechanism and the development of therapeutic strategies. The Sydney Brain Bank is also internationally recognised for its excellence in clinicopathological research due to its standardized collection of brain tissue from prospectively followed cohorts with detailed longitudinal clinical information.
We currently hold brain tissue from over 700 donors with diverse neuropathologies including Alzheimer’s disease, Lewy body disease, motor neuron disease, Huntington’s disease, frontotemporal lobar degeneration, multiple system atrophy, chronic traumatic encephalopathy as well as age-related change. Each year we distribute over 6000 frozen, fixed and slide-mounted tissue specimens to local, national and international research groups to facilitate advances in medical research. The majority of research articles arising from the use of Sydney Brain Bank tissue are published in the top 10% of scientific journals and have a field weighted citation index of 2.43.
How is the Sydney Brain Bank funded?
The Sydney Brain Bank is supported by NeuRA through philanthropic donations made to the NeuRA Foundation, and successfully awarded philanthropic and competitive grant funds.
How can you join a donor program?
Want to learn more about the Sydney Brain Bank and brain donation? Then please head to our Frequently Asked Questions page
SYDNEY BRAIN BANK TEAM
On August 11 2019, 54 people took on the City2Surf for Neuroscience Research Australia (NeuRA). The event is the world’s largest fun run with 80,000 participants taking on the 14km course, which stretches from Hyde Park in central Sydney to the iconic Bondi Beach. NeuRA thanks all of its fundraisers, who raised an incredible $30,903. This funding will further NeuRA’s […]